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High impact information on Coca

  • Cocaine is prepared from the leaves of the plant Erythroxylon coca, and is available as cocaine hydrochloride (a water-soluble powder or granule which can be taken orally, intravenously or intranasally) and as "freebase" or "crack" cocaine (heat stable, melting at high temperatures, thus allowing it to be smoked) [1].
  • Tropane alkaloids from the leaves and stem bark of Erythroxylon alaternifolium and Erythroxylon rotundifolium [2].
  • There have been suggestions that urine samples positive for benzoylecognine, the diagnostic metabolite of cocaine, may be the result of consumption Mate de Coca, a commercially available tea made from coca (Erythroxylon coca) leaves [3].

Associations of Coca with chemical compounds

  • Cocaine, derived from the leaves of the shrub Erythroxylon coca, which grows on the slopes of the Andes, remains one of the most widely abused illicit drugs (Johnson et al., 1993) [4].
  • A novel 3alpha,6beta,7beta-triol tropane alkaloid esterified by two benzoyl residues was isolated from the leaves of the endemic cuban species, Erythroxylon alaternifolium [2].


  1. Cocaine use and cardiovascular complications. Vasica, G., Tennant, C.C. Med. J. Aust. (2002) [Pubmed]
  2. Tropane alkaloids from the leaves and stem bark of Erythroxylon alaternifolium and Erythroxylon rotundifolium. Payo-Hill, A.L., Dominguez, R.S., Suarez, M.O., Batista-Baez, M., Castro, H.T., Rastrelli, L., Aquino, R. Phytochemistry (2000) [Pubmed]
  3. Time for tea, anyone? Turner, M., McCrory, P., Johnston, A. British journal of sports medicine. (2005) [Pubmed]
  4. Body packer: cocaine intoxication, causing death, masked by concomitant administration of major tranquilizers. Klein, C., Balash, Y., Pollak, L., Hiss, J., Rabey, M.J. Eur. J. Neurol. (2000) [Pubmed]
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