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High impact information on Palau

  • A specimen of the ascidian Botrylloides tyreum from Palau contained the known metabolites botryllamides A (5) and C (7) together with four new tyrosine derivatives, botryllamides E-H (1-4), the structures of which were elucidated by interpretation of spectroscopic data [1].
  • The potent antitumor agent dolastatin 10 (1) was originally isolated from the sea hare Dolabella auricularia, and we now report its isolation from the marine cyanobacterium Symploca sp. VP642 from Palau [2].
  • The Palau AHEC has evolved into ajoint activity of JABSOM, the University of Auckland Faculty of Medicine and Health Sciences (UAFMHS), the School of Public Health & Primary Care--Fiji School of Medicine, and Palau Community College to provide Diploma-level training in Family Practice and Community Health for Micronesian physicians [3].
  • In 1997 the courses were extended to include Palau, Yap, Chuuk, Pohnpei, Kosrae, and the Marshall islands [4].
  • Luffolide (4) is a minor metabolite of the sponge Luffariella sp. from Palau [5].

Associations of Palau with chemical compounds

  • The results obtained, taken together with those previously found (Subirana, J.A., Cozcolluela, C., Palau, J. and Unzeta, M. (1973) biochim. Biophys. Acta 317, 364--379), show that in all the molluscs studied one or more arginine-rich components are present [6].


  1. Botryllamides E-H, four new tyrosine derivatives from the ascidian Botrylloides tyreum. Rao, M.R., Faulkner, D.J. J. Nat. Prod. (2004) [Pubmed]
  2. Isolation of dolastatin 10 from the marine cyanobacterium Symploca species VP642 and total stereochemistry and biological evaluation of its analogue symplostatin 1. Luesch, H., Moore, R.E., Paul, V.J., Mooberry, S.L., Corbett, T.H. J. Nat. Prod. (2001) [Pubmed]
  3. In-country and community-based postgraduate family practice training for Micronesian physicians--the Palau AHEC: a collaborative effort. Dever, G., Finau, S.A., McCormick, R., Kuartei, S., Withy, K., Yano, V., Palafox, N., Ueda, M., Pierantozzi, S., Pretrick, E., Ngaden, V., Durand, A.M. Pacific health dialog : a publication of the Pacific Basin Officers Training Program and the Fiji School of Medicine. (2002) [Pubmed]
  4. Distance nursing education in Micronesia. Fochtman, M.M. Pacific health dialog : a publication of the Pacific Basin Officers Training Program and the Fiji School of Medicine. (2000) [Pubmed]
  5. Luffolide, a novel anti-inflammatory terpene from the sponge Luffariella sp.. Kernan, M.R., Faulkner, D.J., Parkanyi, L., Clardy, J., de Carvalho, M.S., Jacobs, R.S. Experientia (1989) [Pubmed]
  6. Protamines and related proteins from spermatozoa of molluscs. Characterization and molecular weight determination by gel electrophoresis. Colom, J., Subirana, J.A. Biochim. Biophys. Acta (1979) [Pubmed]
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