Gene Review:
MANF - mesencephalic astrocyte-derived...
Homo sapiens
Synonyms:
ARMET, ARP, Arginine-rich protein, Mesencephalic astrocyte-derived neurotrophic factor, Protein ARMET
- Mutations in the arginine-rich protein gene, in lung, breast, and prostate cancers, and in squamous cell carcinoma of the head and neck. Shridhar, R., Shridhar, V., Rivard, S., Siegfried, J.M., Pietraszkiewicz, H., Ensley, J., Pauley, R., Grignon, D., Sakr, W., Miller, O.J., Smith, D.I. Cancer Res. (1996)
- Mutations in the arginine-rich protein gene (ARP) in pancreatic cancer. Shridhar, V., Rivard, S., Wang, X., Shridhar, R., Paisley, C., Mullins, C., Beirnat, L., Dugan, M., Sarkar, F., Miller, O.J., Vaitkevicius, V.K., Smith, D.I. Oncogene (1997)
- A gene from human chromosomal band 3p21.1 encodes a highly conserved arginine-rich protein and is mutated in renal cell carcinomas. Shridhar, V., Rivard, S., Shridhar, R., Mullins, C., Bostick, L., Sakr, W., Grignon, D., Miller, O.J., Smith, D.I. Oncogene (1996)
- Polymorphic variation of the ARP gene on 3p21 in Japanese esophageal cancer patients. Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., Ishizaki, K. Oncol. Rep. (2000)
- HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. Malim, M.H., Tiley, L.S., McCarn, D.F., Rusche, J.R., Hauber, J., Cullen, B.R. Cell (1990)
- Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Canagarajah, B.J., Khokhlatchev, A., Cobb, M.H., Goldsmith, E.J. Cell (1997)
- Arginine-rich histones do not exchange between human and mouse chromosomes in hybrid cells. Manser, T., Thacher, T., Rechsteiner, M. Cell (1980)
- Defective high-density lipoprotein composition in patients on chronic hemodialysis. A possible mechanism for accelerated atherosclerosis. Rapoport, J., Aviram, M., Chaimovitz, C., Brook, J.G. N. Engl. J. Med. (1978)
- Exonic splicing enhancers in fission yeast: functional conservation demonstrates an early evolutionary origin. Webb, C.J., Romfo, C.M., van Heeckeren, W.J., Wise, J.A. Genes Dev. (2005)
- Developmental regulation of SR protein phosphorylation and activity. Sanford, J.R., Bruzik, J.P. Genes Dev. (1999)
- The extracellular matrix on atherogenesis and diabetes-associated vascular disease. Camejo, G., Olsson, U., Hurt-Camejo, E., Baharamian, N., Bondjers, G. Atherosclerosis. Supplements. (2002)
- Structural variety of arginine-rich RNA-binding peptides. Tan, R., Frankel, A.D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Gene activation by Varicella-zoster virus IE4 protein requires its dimerization and involves both the arginine-rich sequence, the central part, and the carboxyl-terminal cysteine-rich region. Baudoux, L., Defechereux, P., Rentier, B., Piette, J. J. Biol. Chem. (2000)
- The Gly/Arg-rich (GAR) domain of Xenopus nucleolin facilitates in vitro nucleic acid binding and in vivo nucleolar localization. Heine, M.A., Rankin, M.L., DiMario, P.J. Mol. Biol. Cell (1993)
- Cytokine induction by the hepatitis B virus capsid in macrophages is facilitated by membrane heparan sulfate and involves TLR2. Cooper, A., Tal, G., Lider, O., Shaul, Y. J. Immunol. (2005)
- A novel splicing regulator shares a nuclear import pathway with SR proteins. Lai, M.C., Kuo, H.W., Chang, W.C., Tarn, W.Y. EMBO J. (2003)
- Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA. Romac, J.M., Keene, J.D. Genes Dev. (1995)
- Heterologous basic domain substitutions in the HIV-1 Tat protein reveal an arginine-rich motif required for transactivation. Subramanian, T., Govindarajan, R., Chinnadurai, G. EMBO J. (1991)
- The ER repeat protein YT521-B localizes to a novel subnuclear compartment. Nayler, O., Hartmann, A.M., Stamm, S. J. Cell Biol. (2000)
- Interactions of C-reactive protein with the complement system. II. C-reactive protein-mediated consumption of complement by poly-L-lysine polymers and other polycations. Siegel, J., Osmand, A.P., Wilson, M.F., Gewurz, H. J. Exp. Med. (1975)
- Radioimmunoassay of human arginine-rich apolipoprotein, apoprotein E. Concentration in blood plasma and lipoproteins as affected by apoprotein E-3 deficiency. Havel, R.J., Kotite, L., Vigne, J.L., Kane, J.P., Tun, P., Phillips, N., Chen, G.C. J. Clin. Invest. (1980)
- Low levels of eosinophil cationic proteins in patients with asthma. Venge, P., Zetterström, O., Dahl, R., Roxin, L.E., Olsson, I. Lancet (1977)
- Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components. Chaudhary, N., McMahon, C., Blobel, G. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Histone H3 disulfide dimers and nucleosome structure. Camerini-Otero, R.D., Felsenfeld, G. Proc. Natl. Acad. Sci. U.S.A. (1977)
- Alterations in human high-density lipoproteins, with or without increased plasma-cholesterol, induced by diets high in cholesterol. Mahley, R.W., Innerarity, T.L., Bersot, T.P., Lipson, A., Margolis, S. Lancet (1978)
- Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors. Ylikomi, T., Bocquel, M.T., Berry, M., Gronemeyer, H., Chambon, P. EMBO J. (1992)
- Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA. Tanaka, Y., Nureki, O., Kurumizaka, H., Fukai, S., Kawaguchi, S., Ikuta, M., Iwahara, J., Okazaki, T., Yokoyama, S. EMBO J. (2001)
- A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. Schimmang, T., Tollervey, D., Kern, H., Frank, R., Hurt, E.C. EMBO J. (1989)
- Type III hyperlipoproteinemia: paradoxical hypolipidemic response to estrogen. Kushwaha, R.S., Hazzard, W.R., Gagne, C., Chait, A., Albers, J.J. Ann. Intern. Med. (1977)
- Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. Barboric, M., Kohoutek, J., Price, J.P., Blazek, D., Price, D.H., Peterlin, B.M. EMBO J. (2005)
- Nuclear Transport of Ras-associated Tumor Suppressor Proteins: Different Transport Receptor Binding Specificities for Arginine-rich Nuclear Targeting Signals. Kumari, G., Singhal, P.K., Rao, M.R., Mahalingam, S. J. Mol. Biol. (2007)
- An unusual form of purifying selection in a sperm protein. Rooney, A.P., Zhang, J., Nei, M. Mol. Biol. Evol. (2000)
- RNase S complex bearing arginine-rich peptide and anti-HIV activity. Futaki, S., Nakase, I., Suzuki, T., Nameki, D., Kodama, E., Matsuoka, M., Sugiura, Y. J. Mol. Recognit. (2005)
- Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites. Hendrixson, D.R., Qiu, J., Shewry, S.C., Fink, D.L., Petty, S., Baker, E.N., Plaut, A.G., St Geme, J.W. Mol. Microbiol. (2003)
- Electrochemical assay of plasminogen activators in plasma using polyion-sensitive membrane electrode detection. Chang, L.C., Meyerhoff, M.E., Yang, V.C. Anal. Biochem. (1999)
- The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. Straub, T., Grue, P., Uhse, A., Lisby, M., Knudsen, B.R., Tange, T.O., Westergaard, O., Boege, F. J. Biol. Chem. (1998)
- A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb. Yik, J.H., Chen, R., Pezda, A.C., Samford, C.S., Zhou, Q. Mol. Cell. Biol. (2004)
- Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis. Bae, D.G., Gho, Y.S., Yoon, W.H., Chae, C.B. J. Biol. Chem. (2000)
- Resistance to mitomycin C requires direct interaction between the Fanconi anemia proteins FANCA and FANCG in the nucleus through an arginine-rich domain. Kruyt, F.A., Abou-Zahr, F., Mok, H., Youssoufian, H. J. Biol. Chem. (1999)
- Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Rizos, H., Darmanian, A.P., Mann, G.J., Kefford, R.F. Oncogene (2000)
- Arginine-rich cationic polypeptides amplify lipopolysaccharide-induced monocyte activation. Bosshart, H., Heinzelmann, M. Infect. Immun. (2002)
- Plasma arginine and citrulline kinetics in adults given adequate and arginine-free diets. Castillo, L., Chapman, T.E., Sanchez, M., Yu, Y.M., Burke, J.F., Ajami, A.M., Vogt, J., Young, V.R. Proc. Natl. Acad. Sci. U.S.A. (1993)
- Hepatitis B virus DNA-negative dane particles lack core protein but contain a 22-kDa precore protein without C-terminal arginine-rich domain. Kimura, T., Ohno, N., Terada, N., Rokuhara, A., Matsumoto, A., Yagi, S., Tanaka, E., Kiyosawa, K., Ohno, S., Maki, N. J. Biol. Chem. (2005)
- A region of the Epstein-Barr virus (EBV) mRNA export factor EB2 containing an arginine-rich motif mediates direct binding to RNA. Hiriart, E., Bardouillet, L., Manet, E., Gruffat, H., Penin, F., Montserret, R., Farjot, G., Sergeant, A. J. Biol. Chem. (2003)
- A human RNA polymerase II-containing complex associated with factors necessary for spliceosome assembly. Robert, F., Blanchette, M., Maes, O., Chabot, B., Coulombe, B. J. Biol. Chem. (2002)
- Complexes of the arginine-rich histone tetramer (H3)2(H4)2 with negatively supercoiled DNA: electron microscopy and chemical cross-linking. Thomas, J.O., Oudet, P. Nucleic Acids Res. (1979)