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MeSH Review

Contig Mapping

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High impact information on Contig Mapping

  • The framework map will provide the basis for the detailed physical YAC clone contig mapping of this region, and facilitate the identification and characterization of the Sai1 locus [1].
  • The hDGK epsilon gene was then localized to one of the YAC clones containing a STS marker for the RP17 locus by YAC contig mapping [2].
  • As part of a physical and genetic study of this genomic region, we constructed a 1.5-Mb YAC contig mapping to 10q25 that contains MXI1 and ADRA2A as well as a number of STSs [3].
  • This contig mapping provides the basis for cloning of this interval and for isolation of the NPH1 gene [4].
  • In the program, PCAP, we provide a methodology for choosing synthetic oligonucleotide probes to be used in contig mapping experiments [5].

Biological context of Contig Mapping


  1. A dual-color FISH framework map for the characterization of the Sai1 tumor suppression region on rat chromosome 5. Helou, K., Lü, X.C., Montelius-Alatalo, K., Ståhl, F., Klinga-Levan, K., Levan, G., Röhme, D. Genes Chromosomes Cancer (2000) [Pubmed]
  2. Characterization of the human diacylglycerol kinase epsilon gene and its assessment as a candidate for inherited retinitis pigmentosa. Tang, W., Bardien, S., Bhattacharya, S.S., Prescott, S.M. Gene (1999) [Pubmed]
  3. Detailed physical analysis of a 1.5-megabase YAC contig containing the MXI1 and ADRA2A genes. Manca, A., Volpi, E.V., Laficara, F., Muresu, R., Gray, I.C., Spurr, N.K., Nobile, C. Genomics (1997) [Pubmed]
  4. Refined genetic mapping of a gene for familial juvenile nephronophthisis (NPH1) and physical mapping of linked markers. APN Study Group. Hildebrandt, F., Singh-Sawhney, I., Schnieders, B., Papenfuss, T., Brandis, M. Genomics (1995) [Pubmed]
  5. PCAP: probe choice and analysis package--a set of programs to aid in choosing synthetic oligomers for contig mapping. Cuticchia, A.J., Arnold, J., Timberlake, W.E. Comput. Appl. Biosci. (1993) [Pubmed]
  6. CMAP: contig mapping and analysis package, a relational database for chromosome reconstruction. Cuticchia, A.J., Arnold, J., Brody, H., Timberlake, W.E. Comput. Appl. Biosci. (1992) [Pubmed]
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