Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Cytogenetic Analysis

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Disease relevance of Cytogenetic Analysis

A case of acute promyelocytic leukemia (APL) with cryptic PML-RAR alpha fusion on 17q and add(15p) as a secondary abnormality was characterized using molecular cytogenetic techniques [1].

High impact information on Cytogenetic Analysis

CONCLUSIONS--Molecular genetic and molecular cytogenetic techniques represent rapid and complementary approaches to the diagnosis of mutations in the DAX1 gene responsible for AHC and the associated HH [2].
In these two patients, involvement of the MLL gene was analyzed by molecular cytogenetic techniques which also allowed a more precise mapping of the breakpoints [3].
Identification of a non-fluorescent isodicentric Y chromosome by molecular cytogenetic techniques [4].
BACKGROUND: Array CGH (Comparative Genomic Hybridisation) is a molecular cytogenetic technique for the genome wide detection of chromosomal imbalances [5].
In two patients of CML with secondary chromosomal alteration t(4:9:22), molecular cytogenetic technique (FISH) has been carried out which has confirmed the primary observations revealed by the conventional cytogenetic technique [6].

References

Molecular characterization of der(15)t(11;15) as a secondary cytogenetic abnormality in acute promyelocytic leukemia with cryptic PML-RAR alpha fusion on 17q. Wan, T.S., Ma, S.K., Yip, S.F., Yeung, Y.M., Chan, L.C. Cancer Genet. Cytogenet. (2000) [Pubmed]
Diagnosis of X-linked adrenal hypoplasia congenita by mutation analysis of the DAX1 gene. Guo, W., Mason, J.S., Stone, C.G., Morgan, S.A., Madu, S.I., Baldini, A., Lindsay, E.A., Biesecker, L.G., Copeland, K.C., Horlick, M.N. JAMA (1995) [Pubmed]
Two new translocations involving the 11q23 region map outside the MLL locus in myeloid leukemias. Giugliano, E., Rege-Cambrin, G., Scaravaglio, P., Wlodarska, I., Emanuel, B., Stul, M., Serra, A., Tonso, A., Pini, M., Saglio, G., Hagemeijer, A. Haematologica (2002) [Pubmed]
Identification of a non-fluorescent isodicentric Y chromosome by molecular cytogenetic techniques. Macera, M.J., Sherman, J., Shah, H.O., Blumberg, D.L., Buttice, L.S., Lin, J.H., Verma, R.S. Clin. Genet. (1994) [Pubmed]
CGHPRO -- a comprehensive data analysis tool for array CGH. Chen, W., Erdogan, F., Ropers, H.H., Lenzner, S., Ullmann, R. BMC Bioinformatics (2005) [Pubmed]
Usefulness of cytogenetics in leukemias. VinSheth, F.J., Sheth, J.J., Patel, A.I., Shah, A.D., Verhest, A. Indian journal of cancer. (2002) [Pubmed]

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