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MeSH Review

Sandfly fever Naples virus

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Disease relevance of Sandfly fever Naples virus


High impact information on Sandfly fever Naples virus

  • The envelope glycoproteins G1/G2 of Toscana virus (TOSV) seem to have the most important protective role in stimulating antibodies against the disease in humans, as well as antibodies against the Nucleoprotein (N), a partial neutralizing activity [2].
  • RECENT FINDINGS: Diagnosis of Toscana virus infection has been facilitated by new molecular methods and by immunoenzymatic tests based on the recombinant nucleoprotein [3].


  1. Immunoblot detection of antibodies to Toscana virus. Schwarz, T.F., Gilch, S., Pauli, C., Jäger, G. J. Med. Virol. (1996) [Pubmed]
  2. Neutralization of Toscana virus is partially mediated by antibodies to the nucleocapsid protein. Cusi, M.G., Valensin, P.E., Donati, M., Valassina, M. J. Med. Virol. (2001) [Pubmed]
  3. Epidemiological, clinical and laboratory aspects of sandfly fever. Dionisio, D., Esperti, F., Vivarelli, A., Valassina, M. Curr. Opin. Infect. Dis. (2003) [Pubmed]
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