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N  -  nucleoprotein

Oropouche virus

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Disease relevance of N

  • Bunyaviruses are negative stranded RNA viruses with a trisegmented genome, and the large, medium, and small RNA segments encode the polymerase, the glycoproteins, and the nucleoprotein, respectively [1].
  • A transcript from the S segment of the Germiston bunyavirus is uncapped and codes for the nucleoprotein and a nonstructural protein [2].
  • RECENT FINDINGS: Diagnosis of Toscana virus infection has been facilitated by new molecular methods and by immunoenzymatic tests based on the recombinant nucleoprotein [3].

High impact information on N


Analytical, diagnostic and therapeutic context of N

  • All five mutants showed immunofluorescence when cells were stained at 39 degrees C using a double-staining technique employing monoclonal antibodies against the glycoproteins G1 or G2, and polyclonal antibodies against the nucleoprotein, N [7].


  1. Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses. Griot, C., Gonzalez-Scarano, F., Nathanson, N. Annu. Rev. Microbiol. (1993) [Pubmed]
  2. A transcript from the S segment of the Germiston bunyavirus is uncapped and codes for the nucleoprotein and a nonstructural protein. Bouloy, M., Vialat, P., Girard, M., Pardigon, N. J. Virol. (1984) [Pubmed]
  3. Epidemiological, clinical and laboratory aspects of sandfly fever. Dionisio, D., Esperti, F., Vivarelli, A., Valassina, M. Curr. Opin. Infect. Dis. (2003) [Pubmed]
  4. The complete sequence and coding content of snowshoe hare bunyavirus small (S) viral RNA species. Bishop, D.H., Gould, K.G., Akashi, H., Clerx-van Haaster, C.M. Nucleic Acids Res. (1982) [Pubmed]
  5. Bunyavirus nucleoprotein, N, and a non-structural protein, NSS, are coded by overlapping reading frames in the S RNA. Fuller, F., Bhown, A.S., Bishop, D.H. J. Gen. Virol. (1983) [Pubmed]
  6. Protein synthesis in Bunyamwera virus-infected cells. Lazdins, I., Holmes, I.H. J. Gen. Virol. (1979) [Pubmed]
  7. Characterization of two recombination-complementation groups of Uukuniemi virus temperature-sensitive mutants. Gahmberg, N. J. Gen. Virol. (1984) [Pubmed]
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