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MeSH Review

Feline panleukopenia virus

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Disease relevance of Feline panleukopenia virus

  • Feline panleukopenia virus (FPLV) was shown to induce apoptosis to feline lymphoid cells and to reduce the expression of interleukin-2 receptor alpha on the cells [1].
  • Analysis of the ratio of nonsynonymous and synonymous substitutions revealed that synonymous substitutions exceeded nonsynonymous substitutions in both the NS1 and VP2 genes of FPLV, even when the analysis focused on specific regions in the VP2 gene that are known to be located on the capsid surface [2].

High impact information on Feline panleukopenia virus

  • High antigenic homogeneity among FPLV strains was confirmed by HA-inhibition (HI) test with the mAbs and polyclonal immune sera against FPLV or CPV [3].

Gene context of Feline panleukopenia virus

  • A similar tendency, however, was not observed in the FPLV VP2 proteins [2].


  1. Apoptosis in feline panleukopenia virus-infected lymphocytes. Ikeda, Y., Shinozuka, J., Miyazawa, T., Kurosawa, K., Izumiya, Y., Nishimura, Y., Nakamura, K., Cai, J., Fujita, K., Doi, K., Mikami, T. J. Virol. (1998) [Pubmed]
  2. Differences in the evolutionary pattern of feline panleukopenia virus and canine parvovirus. Horiuchi, M., Yamaguchi, Y., Gojobori, T., Mochizuki, M., Nagasawa, H., Toyoda, Y., Ishiguro, N., Shinagawa, M. Virology (1998) [Pubmed]
  3. Comparison of feline parvovirus subspecific strains using monoclonal antibodies against a feline panleukopenia virus. Mochizuki, M., Konishi, S., Ajiki, M., Akaboshi, T. Nippon Juigaku Zasshi (1989) [Pubmed]
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