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Disease relevance of Tymoviridae

  • BmMLV RNA potentially encodes two proteins, putative RNA replicase and coat protein, which share structural features and sequence similarities with those of a plant RNA virus, the genus Maculavirus [1].
  • Phylogenetic analysis of the viral replicase and coat protein genes showed that GFkV is related to members of the Tymovirus and Marafivirus genera [2].

High impact information on Tymoviridae

  • The 3' ends of GAMaV (1852 nt) and of GR8-19 (1791 nt) resembled that of marafiviruses, as both encoded a single putative polyprotein containing the conserved "marafibox" sequence and lacked the stop codon between the replicase and coat protein genes [3].


  1. Novel macula-like virus identified in Bombyx mori cultured cells. Katsuma, S., Tanaka, S., Omuro, N., Takabuchi, L., Daimon, T., Imanishi, S., Yamashita, S., Iwanaga, M., Mita, K., Maeda, S., Kobayashi, M., Shimada, T. J. Virol. (2005) [Pubmed]
  2. Complete nucleotide sequence and genome organization of Grapevine fleck virus. Sabanadzovic, S., Ghanem-Sabanadzovic, N.A., Saldarelli, P., Martelli, G.P. J. Gen. Virol. (2001) [Pubmed]
  3. Sequence analysis of the 3' end of three Grapevine fleck virus-like viruses from grapevine. Ghanem-Sabanadzovic, N.A., Sabanadzovic, S., Martelli, G.P. Virus Genes (2003) [Pubmed]
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