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MeSH Review

Eye Neoplasms

 
 
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Disease relevance of Eye Neoplasms

  • Retinoblastoma (RB) is a childhood eye cancer that arises when a retinal cell lacks a functional RB gene [1].
  • The risk of developing a new cancer was evaluated in 7,211 persons with cutaneous melanoma, 1,784 persons with eye cancer, 10,273 persons with tumors of the brain and nervous system, 1,935 persons with thyroid cancer, 1,542 persons with bone tumors, and 2,318 persons with malignant neoplasms of the connective tissue [2].
 

High impact information on Eye Neoplasms

  • Mutational inactivation of the retinoblastoma gene (RB) is an invariant feature of the childhood eye cancer retinoblastoma and of tumor cells derived therefrom [3].
  • Inhibition of HDM2 can selectively activate p53 in transformed cells and may be an effective strategy for inducing apoptosis in eye cancer cells with minimal damage to normal ocular tissues [4].
  • There were no statistically significant differences in BoLA antigen frequency between cattle with and cattle without cancer-eye [5].
  • A retrospective analysis of primary eye cancer at the University of Alabama 1958-1988. Part 2: Eyelid tumors [6].

References

  1. Five DNA tumor viruses undetectable in human retinoblastomas. Howard, E., Marcus, D., O'Brien, J., Albert, D., Bernards, R. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  2. Second cancer following cutaneous melanoma and cancers of the brain, thyroid, connective tissue, bone, and eye in Denmark, 1943-80. Osterlind, A., Olsen, J.H., Lynge, E., Ewertz, M. National Cancer Institute monograph. (1985) [Pubmed]
  3. Stability of retinoblastoma gene expression determines the tumorigenicity of reconstituted retinoblastoma cells. Chen, P.L., Chen, Y., Shan, B., Bookstein, R., Lee, W.H. Cell Growth Differ. (1992) [Pubmed]
  4. Transducible peptide therapy for uveal melanoma and retinoblastoma. Harbour, J.W., Worley, L., Ma, D., Cohen, M. Arch. Ophthalmol. (2002) [Pubmed]
  5. Failure to find an association between ocular squamous cell carcinoma and class I antigens of the bovine major histocompatibility system. Stear, M.J., Spradbrow, P.B., Tierney, T.J., Nicholas, F.W., Bellows, R.A. Anim. Genet. (1989) [Pubmed]
  6. A retrospective analysis of primary eye cancer at the University of Alabama 1958-1988. Part 2: Eyelid tumors. Swanson, M.W., Cloud, G. Journal of the American Optometric Association. (1991) [Pubmed]
 
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