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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Connective Tissue

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Disease relevance of Connective Tissue


Psychiatry related information on Connective Tissue


High impact information on Connective Tissue


Chemical compound and disease context of Connective Tissue


Biological context of Connective Tissue


Anatomical context of Connective Tissue


Associations of Connective Tissue with chemical compounds


Gene context of Connective Tissue

  • COL1A1 is a major constituent of the connective tissue matrix [35].
  • Absence of TNX mRNA and protein in the proband, mapping of the TNX gene and HLA typing of this family suggest recessive inheritance of TNX deficiency and connective-tissue disease [25].
  • Although the precise role of TNX in the pathogenesis of EDS is uncertain, this patient's findings suggest a unique and essential role for TNX in connective-tissue structure and function [25].
  • However, targetted inactivation of the Pdgfb gene or the Pdgf receptor beta (Pdgfrb) gene, by homologous recombination, does not prevent the development of apparently normal large arteries and connective tissue [36].
  • Human platelet-derived growth factor (PDGF) is a connective tissue cell mitogen comprised of two related chains encoded by distinct genes [37].

Analytical, diagnostic and therapeutic context of Connective Tissue


  1. Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome. Neptune, E.R., Frischmeyer, P.A., Arking, D.E., Myers, L., Bunton, T.E., Gayraud, B., Ramirez, F., Sakai, L.Y., Dietz, H.C. Nat. Genet. (2003) [Pubmed]
  2. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S.A., Mankani, M., Robey, P.G., Poole, A.R., Pidoux, I., Ward, J.M., Birkedal-Hansen, H. Cell (1999) [Pubmed]
  3. International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Bathgate, R.A., Ivell, R., Sanborn, B.M., Sherwood, O.D., Summers, R.J. Pharmacol. Rev. (2006) [Pubmed]
  4. Bronchiolitis and bronchitis in connective tissue disease. A possible relationship to the use of penicillamine. Epler, G.R., Snider, G.L., Gaensler, E.A., Cathcart, E.S., FitzGerald, M.X., Carrington, C.B. JAMA (1979) [Pubmed]
  5. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. Fava, R.A., Olsen, N.J., Postlethwaite, A.E., Broadley, K.N., Davidson, J.M., Nanney, L.B., Lucas, C., Townes, A.S. J. Exp. Med. (1991) [Pubmed]
  6. Distribution of an anti-DNA idiotype among autoantibodies in patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). Harkiss, G.D., Hendrie, F., Nuki, G. J. Clin. Immunol. (1986) [Pubmed]
  7. Metabolism of collagen in aspartylglycosaminuria: urinary excretion of hydroxyproline. Näntö-Salonen, K., Autio, S., Härö, E., Kivimäki, T., Koskela, S.L., Näntö, V., Penttinen, R. J. Inherit. Metab. Dis. (1984) [Pubmed]
  8. Age-dependent changes in the response of the stomach to thyroidal signaling in developmentally arrested larval summer flounder. Soffientino, B., Specker, J.L. Gen. Comp. Endocrinol. (2003) [Pubmed]
  9. Cerebral amyloid angiopathy and dementia. Tian, J., Shi, J., Mann, D.M. Panminerva medica. (2004) [Pubmed]
  10. Biochemistry and genetics of von Willebrand factor. Sadler, J.E. Annu. Rev. Biochem. (1998) [Pubmed]
  11. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Kjaer, M. Physiol. Rev. (2004) [Pubmed]
  12. Mechanism of action and in vivo role of platelet-derived growth factor. Heldin, C.H., Westermark, B. Physiol. Rev. (1999) [Pubmed]
  13. A functional SNP in CILP, encoding cartilage intermediate layer protein, is associated with susceptibility to lumbar disc disease. Seki, S., Kawaguchi, Y., Chiba, K., Mikami, Y., Kizawa, H., Oya, T., Mio, F., Mori, M., Miyamoto, Y., Masuda, I., Tsunoda, T., Kamata, M., Kubo, T., Toyama, Y., Kimura, T., Nakamura, Y., Ikegawa, S. Nat. Genet. (2005) [Pubmed]
  14. Heterozygous TGFBR2 mutations in Marfan syndrome. Mizuguchi, T., Collod-Beroud, G., Akiyama, T., Abifadel, M., Harada, N., Morisaki, T., Allard, D., Varret, M., Claustres, M., Morisaki, H., Ihara, M., Kinoshita, A., Yoshiura, K., Junien, C., Kajii, T., Jondeau, G., Ohta, T., Kishino, T., Furukawa, Y., Nakamura, Y., Niikawa, N., Boileau, C., Matsumoto, N. Nat. Genet. (2004) [Pubmed]
  15. Abnormal fibrillin assembly by dermal fibroblasts from two patients with Marfan syndrome. Kielty, C.M., Shuttleworth, C.A. J. Cell Biol. (1994) [Pubmed]
  16. Diphenylhydantoin (dilantin) gingival hyperplasia: drug-induced abnormality of connective tissue. Hassell, T.M., Page, R.C., Narayanan, A.S., Cooper, C.G. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  17. Patterns of pulmonary structural remodeling after experimental paraquat toxicity. The morphogenesis of intraalveolar fibrosis. Fukuda, Y., Ferrans, V.J., Schoenberger, C.I., Rennard, S.I., Crystal, R.G. Am. J. Pathol. (1985) [Pubmed]
  18. Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan. Mello, L.V., De Groot, B.L., Li, S., Jedrzejas, M.J. J. Biol. Chem. (2002) [Pubmed]
  19. Minocycline-induced hyperpigmentation masquerading as alkaptonuria in individuals with joint pain. Suwannarat, P., Phornphutkul, C., Bernardini, I., Turner, M., Gahl, W.A. Arthritis Rheum. (2004) [Pubmed]
  20. TGF-beta induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Battegay, E.J., Raines, E.W., Seifert, R.A., Bowen-Pope, D.F., Ross, R. Cell (1990) [Pubmed]
  21. Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Sugano, S., Stoeckle, M.Y., Hanafusa, H. Cell (1987) [Pubmed]
  22. Nucleotide sequence analysis identifies the human c-sis proto-oncogene as a structural gene for platelet-derived growth factor. Chiu, I.M., Reddy, E.P., Givol, D., Robbins, K.C., Tronick, S.R., Aaronson, S.A. Cell (1984) [Pubmed]
  23. Two distinct mechanisms of fibroblast adhesion. Harper, P.A., Juliano, R.L. Nature (1981) [Pubmed]
  24. Stimulation of connective tissue cell growth by substance P and substance K. Nilsson, J., von Euler, A.M., Dalsgaard, C.J. Nature (1985) [Pubmed]
  25. Tenascin-X deficiency is associated with Ehlers-Danlos syndrome. Burch, G.H., Gong, Y., Liu, W., Dettman, R.W., Curry, C.J., Smith, L., Miller, W.L., Bristow, J. Nat. Genet. (1997) [Pubmed]
  26. A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. Query, C.C., Keene, J.D. Cell (1987) [Pubmed]
  27. Heparin is essential for the storage of specific granule proteases in mast cells. Humphries, D.E., Wong, G.W., Friend, D.S., Gurish, M.F., Qiu, W.T., Huang, C., Sharpe, A.H., Stevens, R.L. Nature (1999) [Pubmed]
  28. Cephalosporin antibiotics can be modified to inhibit human leukocyte elastase. Doherty, J.B., Ashe, B.M., Argenbright, L.W., Barker, P.L., Bonney, R.J., Chandler, G.O., Dahlgren, M.E., Dorn, C.P., Finke, P.E., Firestone, R.A. Nature (1986) [Pubmed]
  29. Alternatively spliced human tissue factor: a circulating, soluble, thrombogenic protein. Bogdanov, V.Y., Balasubramanian, V., Hathcock, J., Vele, O., Lieb, M., Nemerson, Y. Nat. Med. (2003) [Pubmed]
  30. Pathophysiology of premature skin aging induced by ultraviolet light. Fisher, G.J., Wang, Z.Q., Datta, S.C., Varani, J., Kang, S., Voorhees, J.J. N. Engl. J. Med. (1997) [Pubmed]
  31. The molecular basis of alkaptonuria. Fernández-Cañón, J.M., Granadino, B., Beltrán-Valero de Bernabé, D., Renedo, M., Fernández-Ruiz, E., Peñalva, M.A., Rodríguez de Córdoba, S. Nat. Genet. (1996) [Pubmed]
  32. Silicone breast implants and the risk of connective-tissue diseases and symptoms. Sánchez-Guerrero, J., Colditz, G.A., Karlson, E.W., Hunter, D.J., Speizer, F.E., Liang, M.H. N. Engl. J. Med. (1995) [Pubmed]
  33. Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues. Couchman, J.R., Caterson, B., Christner, J.E., Baker, J.R. Nature (1984) [Pubmed]
  34. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Brownlee, M., Vlassara, H., Kooney, A., Ulrich, P., Cerami, A. Science (1986) [Pubmed]
  35. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma. Simon, M.P., Pedeutour, F., Sirvent, N., Grosgeorge, J., Minoletti, F., Coindre, J.M., Terrier-Lacombe, M.J., Mandahl, N., Craver, R.D., Blin, N., Sozzi, G., Turc-Carel, C., O'Brien, K.P., Kedra, D., Fransson, I., Guilbaud, C., Dumanski, J.P. Nat. Genet. (1997) [Pubmed]
  36. Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages. Crosby, J.R., Seifert, R.A., Soriano, P., Bowen-Pope, D.F. Nat. Genet. (1998) [Pubmed]
  37. Molecular localization of the transforming and secretory properties of PDGF A and PDGF B. LaRochelle, W.J., Giese, N., May-Siroff, M., Robbins, K.C., Aaronson, S.A. Science (1990) [Pubmed]
  38. Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus. Han, V.K., D'Ercole, A.J., Lund, P.K. Science (1987) [Pubmed]
  39. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. Migliaccio, A.R., Rana, R.A., Sanchez, M., Lorenzini, R., Centurione, L., Bianchi, L., Vannucchi, A.M., Migliaccio, G., Orkin, S.H. J. Exp. Med. (2003) [Pubmed]
  40. Scl-86, a marker antigen for diffuse scleroderma. van Venrooij, W.J., Stapel, S.O., Houben, H., Habets, W.J., Kallenberg, C.G., Penner, E., van de Putte, L.B. J. Clin. Invest. (1985) [Pubmed]
  41. Relationship of one form of human histamine-releasing factor to connective tissue activating peptide-III. Baeza, M.L., Reddigari, S.R., Kornfeld, D., Ramani, N., Smith, E.M., Hossler, P.A., Fischer, T., Castor, C.W., Gorevic, P.G., Kaplan, A.P. J. Clin. Invest. (1990) [Pubmed]
  42. beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis. Miyata, T., Oda, O., Inagi, R., Iida, Y., Araki, N., Yamada, N., Horiuchi, S., Taniguchi, N., Maeda, K., Kinoshita, T. J. Clin. Invest. (1993) [Pubmed]
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