Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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MeSH Review:

Chromosomes, Human, Pair 4

Chesi, M. et al., Klyczek, K.K. et al., Rothlind, J.C. et al.

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High impact information on Chromosomes, Human, Pair 4

The chromosome-4 breakpoints are clustered in a 70-kb region centromeric to the fibroblast growth factor receptor 3 gene (FGFR3), the apparent dysregulated oncogene [1].
T cell surface I-J glycoprotein. Concerted action of chromosome-4 and -17 genes forms an epitope dependent on alpha-D-mannosyl residues [2].
Presence of the chromosome-4 DNA marker linked to the HD phenotype was the criterion for HD risk [3].

References

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Chesi, M., Nardini, E., Brents, L.A., Schröck, E., Ried, T., Kuehl, W.M., Bergsagel, P.L. Nat. Genet. (1997) [Pubmed]
T cell surface I-J glycoprotein. Concerted action of chromosome-4 and -17 genes forms an epitope dependent on alpha-D-mannosyl residues. Klyczek, K.K., Cantor, H., Hayes, C.E. J. Exp. Med. (1984) [Pubmed]
Unimpaired verbal memory and oculomotor control in asymptomatic adults with the genetic marker for Huntington's disease. Rothlind, J.C., Brandt, J., Zee, D., Codori, A.M., Folstein, S. Arch. Neurol. (1993) [Pubmed]

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