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MeSH Review

Dog Diseases

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High impact information on Dog Diseases

  • The canine disease, X-linked progressive retinal atrophy (XLPRA), is similar to human RP3, an X-linked form of retinitis pigmentosa, and maps to the same region in the X chromosome [1].
  • To date no initiating agent has been identified, but this spontaneous canine disease which is very similar to human RA can provide a valuable model in which to examine pathogenesis of chronic arthritis [2].
  • The comparable region of the human X chromosome includes the disease locus for RP3, an X-linked form of retinitis pigmentosa, although the current canine disease interval is much larger [3].
  • Moreover, alleles of the canine CLN3 gene distinguished by an intragenic marker segregated independently from the disease in an English setter family, eliminating CLN3 as the locus for the canine disease [4].
  • No significant cross reactivity was observed with sera of animals with other common canine diseases [5].

Gene context of Dog Diseases


  1. Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration. Zhang, Q., Acland, G.M., Wu, W.X., Johnson, J.L., Pearce-Kelling, S., Tulloch, B., Vervoort, R., Wright, A.F., Aguirre, G.D. Hum. Mol. Genet. (2002) [Pubmed]
  2. Synovial pathologic changes in spontaneous canine rheumatoid-like arthritis. Schumacher, H.R., Newton, C., Halliwell, R.E. Arthritis Rheum. (1980) [Pubmed]
  3. Fine mapping of canine XLPRA establishes homology of the human and canine RP3 intervals. Zhang, Q., Acland, G.M., Zangerl, B., Johnson, J.L., Mao, Z., Zeiss, C.J., Ostrander, E.A., Aguirre, G.D. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  4. Coding sequence and exon/intron organization of the canine CLN3 (Batten disease) gene and its exclusion as the locus for ceroid-lipofuscinosis in English setter dogs. Shibuya, H., Liu, P.C., Katz, M.L., Siakotos, A.N., Nonneman, D.J., Johnson, G.S. J. Neurosci. Res. (1998) [Pubmed]
  5. Diagnosis of American visceral leishmaniasis in humans and dogs using the recombinant Leishmania donovani A2 antigen. Carvalho, F.A., Charest, H., Tavares, C.A., Matlashewski, G., Valente, E.P., Rabello, A., Gazzinelli, R.T., Fernandes, A.P. Diagn. Microbiol. Infect. Dis. (2002) [Pubmed]
  6. Autoantibody profiles in canine ANA-positive sera investigated by immunoblot and ELISA. Welin Henriksson, E., Hansson, H., Karlsson-Parra, A., Pettersson, I. Vet. Immunol. Immunopathol. (1998) [Pubmed]
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