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Gene Review

SLEB3  -  systemic lupus erythematosus susceptibility 3

Homo sapiens

 
 
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Disease relevance of SLEB3

 

Psychiatry related information on SLEB3

 

High impact information on SLEB3

 

Chemical compound and disease context of SLEB3

 

Biological context of SLEB3

  • We found the maximum multipoint parametric LOD score was 5.19 and the non-parametric linkage score (Zlr) was 3.12 ( P=9x10(-4)) for EA NP pedigrees at 4p16, previously identified as SLEB3 [19].
  • Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects [20].
  • Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees [20].
  • Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2 [21].
  • In an effort to identify new susceptibility loci for SLE, we recently reported the results of a genomewide microsatellite marker screen in 105 SLE sib-pair families [1].
 

Anatomical context of SLEB3

 

Associations of SLEB3 with chemical compounds

 

Physical interactions of SLEB3

 

Enzymatic interactions of SLEB3

 

Regulatory relationships of SLEB3

 

Other interactions of SLEB3

  • Therefore, our results have detected, established, and confirmed the existence of a novel SLE susceptibility locus at 12q24 (designated "SLEB4") that may cause lupus, especially in Hispanic and European American families [43].
  • We predicted that pedigrees multiplex for both SLE and for self-reported RA would better isolate particular genetic effects [2].
  • CONCLUSIONS: A differential association between HLA-DR, DQA1, and DQB1 alleles and SLE or its clinical and serological manifestations are found [44].
  • We found that the polymorphism was associated with differences in baseline CRP in both normal individuals and in patients with the inflammatory disease systemic lupus erythematosus, viz. donors carrying two GT(16) alleles, two GT(21)alleles, or GT(16/21) heterozygotes had two-fold lower serum CRP than those with other genotypes [45].
  • A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans [46].
 

Analytical, diagnostic and therapeutic context of SLEB3

References

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  2. Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Namjou, B., Nath, S.K., Kilpatrick, J., Kelly, J.A., Reid, J., James, J.A., Harley, J.B. Arthritis Rheum. (2002) [Pubmed]
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  46. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Prokunina, L., Castillejo-López, C., Oberg, F., Gunnarsson, I., Berg, L., Magnusson, V., Brookes, A.J., Tentler, D., Kristjansdóttir, H., Gröndal, G., Bolstad, A.I., Svenungsson, E., Lundberg, I., Sturfelt, G., Jönssen, A., Truedsson, L., Lima, G., Alcocer-Varela, J., Jonsson, R., Gyllensten, U.B., Harley, J.B., Alarcón-Segovia, D., Steinsson, K., Alarcón-Riquelme, M.E. Nat. Genet. (2002) [Pubmed]
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