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Gene Review

SLEB3  -  systemic lupus erythematosus susceptibility 3

Homo sapiens

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Disease relevance of SLEB3


Psychiatry related information on SLEB3


High impact information on SLEB3


Chemical compound and disease context of SLEB3


Biological context of SLEB3

  • We found the maximum multipoint parametric LOD score was 5.19 and the non-parametric linkage score (Zlr) was 3.12 ( P=9x10(-4)) for EA NP pedigrees at 4p16, previously identified as SLEB3 [19].
  • Our results are consistent with the presumed complexity of genetic susceptibility to SLE and illustrate racial origin is likely to influence the specific nature of these genetic effects [20].
  • Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees [20].
  • Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2 [21].
  • In an effort to identify new susceptibility loci for SLE, we recently reported the results of a genomewide microsatellite marker screen in 105 SLE sib-pair families [1].

Anatomical context of SLEB3


Associations of SLEB3 with chemical compounds


Physical interactions of SLEB3


Enzymatic interactions of SLEB3


Regulatory relationships of SLEB3


Other interactions of SLEB3

  • Therefore, our results have detected, established, and confirmed the existence of a novel SLE susceptibility locus at 12q24 (designated "SLEB4") that may cause lupus, especially in Hispanic and European American families [43].
  • We predicted that pedigrees multiplex for both SLE and for self-reported RA would better isolate particular genetic effects [2].
  • CONCLUSIONS: A differential association between HLA-DR, DQA1, and DQB1 alleles and SLE or its clinical and serological manifestations are found [44].
  • We found that the polymorphism was associated with differences in baseline CRP in both normal individuals and in patients with the inflammatory disease systemic lupus erythematosus, viz. donors carrying two GT(16) alleles, two GT(21)alleles, or GT(16/21) heterozygotes had two-fold lower serum CRP than those with other genotypes [45].
  • A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans [46].

Analytical, diagnostic and therapeutic context of SLEB3


  1. Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Gaffney, P.M., Ortmann, W.A., Selby, S.A., Shark, K.B., Ockenden, T.C., Rohlf, K.E., Walgrave, N.L., Boyum, W.P., Malmgren, M.L., Miller, M.E., Kearns, G.M., Messner, R.P., King, R.A., Rich, S.S., Behrens, T.W. Am. J. Hum. Genet. (2000) [Pubmed]
  2. Stratification of pedigrees multiplex for systemic lupus erythematosus and for self-reported rheumatoid arthritis detects a systemic lupus erythematosus susceptibility gene (SLER1) at 5p15.3. Namjou, B., Nath, S.K., Kilpatrick, J., Kelly, J.A., Reid, J., James, J.A., Harley, J.B. Arthritis Rheum. (2002) [Pubmed]
  3. Differential contribution of C4 and HLA-DQ genes to systemic lupus erythematosus susceptibility. De Juan, D., Martín-Villa, J.M., Gómez-Reino, J.J., Vicario, J.L., Corell, A., Martínez-Laso, J., Benmammar, D., Arnaiz-Villena, A. Hum. Genet. (1993) [Pubmed]
  4. The long-term clinical course of systemic lupus erythematosus in end-stage renal disease. Coplon, N.S., Diskin, C.J., Petersen, J., Swenson, R.S. N. Engl. J. Med. (1983) [Pubmed]
  5. High-frequency representation of a single VH gene in the expressed human B cell repertoire. Stewart, A.K., Huang, C., Stollar, B.D., Schwartz, R.S. J. Exp. Med. (1993) [Pubmed]
  6. From the Cover: Human lupus autoantibodies against NMDA receptors mediate cognitive impairment. Kowal, C., Degiorgio, L.A., Lee, J.Y., Edgar, M.A., Huerta, P.T., Volpe, B.T., Diamond, B. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  7. The relationship of socioeconomic status, race, and modifiable risk factors to outcomes in patients with systemic lupus erythematosus. Karlson, E.W., Daltroy, L.H., Lew, R.A., Wright, E.A., Partridge, A.J., Fossel, A.H., Roberts, W.N., Stern, S.H., Straaton, K.V., Wacholtz, M.C., Kavanaugh, A.F., Grosflam, J.M., Liang, M.H. Arthritis Rheum. (1997) [Pubmed]
  8. A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Karlson, E.W., Liang, M.H., Eaton, H., Huang, J., Fitzgerald, L., Rogers, M.P., Daltroy, L.H. Arthritis Rheum. (2004) [Pubmed]
  9. A controlled study of the prevalence of cognitive dysfunction in randomly selected patients with systemic lupus erythematosus. Ginsburg, K.S., Wright, E.A., Larson, M.G., Fossel, A.H., Albert, M., Schur, P.H., Liang, M.H. Arthritis Rheum. (1992) [Pubmed]
  10. Genetic susceptibility to systemic lupus erythematosus. Vyse, T.J., Kotzin, B.L. Annu. Rev. Immunol. (1998) [Pubmed]
  11. Neuroendocrine-immune system interactions and autoimmunity. Wilder, R.L. Annu. Rev. Immunol. (1995) [Pubmed]
  12. Statistical false positive or true disease pathway? Todd, J.A. Nat. Genet. (2006) [Pubmed]
  13. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Kochi, Y., Yamada, R., Suzuki, A., Harley, J.B., Shirasawa, S., Sawada, T., Bae, S.C., Tokuhiro, S., Chang, X., Sekine, A., Takahashi, A., Tsunoda, T., Ohnishi, Y., Kaufman, K.M., Kang, C.P., Kang, C., Otsubo, S., Yumura, W., Mimori, A., Koike, T., Nakamura, Y., Sasazuki, T., Yamamoto, K. Nat. Genet. (2005) [Pubmed]
  14. A controlled trial of plasmapheresis therapy in severe lupus nephritis. The Lupus Nephritis Collaborative Study Group. Lewis, E.J., Hunsicker, L.G., Lan, S.P., Rohde, R.D., Lachin, J.M. N. Engl. J. Med. (1992) [Pubmed]
  15. Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. Lockshin, M.D., Druzin, M.L., Goei, S., Qamar, T., Magid, M.S., Jovanovic, L., Ferenc, M. N. Engl. J. Med. (1985) [Pubmed]
  16. Nifedipine in the treatment of migraine headache and amaurosis fugax in patients with systemic lupus erythematosus. Miller, F.W., Santoro, T.J. N. Engl. J. Med. (1984) [Pubmed]
  17. Prevalence of congenital or acquired complement deficiency in patients with sporadic meningocococcal disease. Ellison, R.T., Kohler, P.F., Curd, J.G., Judson, F.N., Reller, L.B. N. Engl. J. Med. (1983) [Pubmed]
  18. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. DeGiorgio, L.A., Konstantinov, K.N., Lee, S.C., Hardin, J.A., Volpe, B.T., Diamond, B. Nat. Med. (2001) [Pubmed]
  19. SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations. Nath, S.K., Kelly, J.A., Reid, J., Lam, T., Gray-McGuire, C., Namjou, B., Aston, C.E., Harley, J.B. Hum. Genet. (2002) [Pubmed]
  20. Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Moser, K.L., Neas, B.R., Salmon, J.E., Yu, H., Gray-McGuire, C., Asundi, N., Bruner, G.R., Fox, J., Kelly, J., Henshall, S., Bacino, D., Dietz, M., Hogue, R., Koelsch, G., Nightingale, L., Shaver, T., Abdou, N.I., Albert, D.A., Carson, C., Petri, M., Treadwell, E.L., James, J.A., Harley, J.B. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  21. Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Gray-McGuire, C., Moser, K.L., Gaffney, P.M., Kelly, J., Yu, H., Olson, J.M., Jedrey, C.M., Jacobs, K.B., Kimberly, R.P., Neas, B.R., Rich, S.S., Behrens, T.W., Harley, J.B. Am. J. Hum. Genet. (2000) [Pubmed]
  22. Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci. Trevisan, G.L., Rassi, D.M., Baião, A.M., Sandrin-Garcia, P., Mello, S.S., Tamia-Ferreira, M.C., Junta, C.M., Fachin, A.L., Marques, M.M., Sakamoto-Hojo, E.T., Donadi, E.A., Passos, G.A. Autoimmunity reviews. (2006) [Pubmed]
  23. Predominance of T cells in pleural fluid of a patient with systemic lupus erythematosus. Michalevicz, R., Many, A. N. Engl. J. Med. (1977) [Pubmed]
  24. Adherence of human peripheral blood lymphycytes to measles-infected cells. Enhancement by prostaglandin E1. Zurier, R.B., Dore-Duffy, P., Viola, M.V. N. Engl. J. Med. (1977) [Pubmed]
  25. Clinical and immunologic effects of monthly administration of intravenous cyclophosphamide in severe systemic lupus erythematosus. McCune, W.J., Golbus, J., Zeldes, W., Bohlke, P., Dunne, R., Fox, D.A. N. Engl. J. Med. (1988) [Pubmed]
  26. Mode of inheritance of decreased C3b receptors on erythrocytes of patients with systemic lupus erythematosus. Wilson, J.G., Wong, W.W., Schur, P.H., Fearon, D.T. N. Engl. J. Med. (1982) [Pubmed]
  27. Cutaneous localization of the membrane attack complex in discoid and systemic lupus erythematosus. Biesecker, G., Lavin, L., Ziskind, M., Koffler, D. N. Engl. J. Med. (1982) [Pubmed]
  28. Hydroxychloroquine in systemic lupus erythematosus. Disla, E., Brar, H., Taranta, A. N. Engl. J. Med. (1991) [Pubmed]
  29. Aspirin-induced depression of renal function. Kimberly, R.P., Plotz, P.H. N. Engl. J. Med. (1977) [Pubmed]
  30. Letter: Ibuprofen for systemic lupus erythematosus. Dubois, E.L. N. Engl. J. Med. (1975) [Pubmed]
  31. Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus. Kyttaris, V.C., Juang, Y.T., Tenbrock, K., Weinstein, A., Tsokos, G.C. J. Immunol. (2004) [Pubmed]
  32. Vasoactive intestinal peptide binding autoantibodies in autoimmune humans and mice. Bangale, Y., Cavill, D., Gordon, T., Planque, S., Taguchi, H., Bhatia, G., Nishiyama, Y., Arnett, F., Paul, S. Peptides (2002) [Pubmed]
  33. Association of leukocyte CR1 gene transcription with the disease severity and renal involvement in systemic lupus erythematosus. Verma, J., Arora, V., Marwaha, V., Kumar, A., Das, N. Lupus (2005) [Pubmed]
  34. Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunity. James, J.A., Gross, T., Scofield, R.H., Harley, J.B. J. Exp. Med. (1995) [Pubmed]
  35. Acquired deficiency of von Willebrand factor-cleaving protease in a patient suffering from acute systemic lupus erythematosus. Güngör, T., Furlan, M., Lämmle, B., Kuhn, F., Seger, R.A. Rheumatology (Oxford, England) (2001) [Pubmed]
  36. Autoantibodies to topoisomerase I in a patient with systemic lupus erythematosus without features of scleroderma. Stojanov, L., Satoh, M., Dooley, M.A., Kuwana, M., Jennette, J.C., Reeves, W.H. Lupus (1995) [Pubmed]
  37. Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B. Beyer, T.D., Kolowos, W., Dumitriu, I.E., Voll, R.E., Heyder, P., Gaipl, U.S., Kalden, J.R., Herrmann, M. Scand. J. Immunol. (2002) [Pubmed]
  38. Expansion of toll-like receptor 9-expressing B cells in active systemic lupus erythematosus: implications for the induction and maintenance of the autoimmune process. Papadimitraki, E.D., Choulaki, C., Koutala, E., Bertsias, G., Tsatsanis, C., Gergianaki, I., Raptopoulou, A., Kritikos, H.D., Mamalaki, C., Sidiropoulos, P., Boumpas, D.T. Arthritis Rheum. (2006) [Pubmed]
  39. Interleukin-10 response abnormalities in systemic lupus erythematosus. Mongan, A.E., Ramdahin, S., Warrington, R.J. Scand. J. Immunol. (1997) [Pubmed]
  40. Etanercept-induced systemic lupus erythematosus. Swale, V.J., Perrett, C.M., Denton, C.P., Black, C.M., Rustin, M.H. Clin. Exp. Dermatol. (2003) [Pubmed]
  41. Von Willebrand factor cleaving protease (ADAMTS-13) in 123 patients with connective tissue diseases (systemic lupus erythematosus and systemic sclerosis). Mannucci, P.M., Vanoli, M., Forza, I., Canciani, M.T., Scorza, R. Haematologica (2003) [Pubmed]
  42. BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction. Dzionek, A., Sohma, Y., Nagafune, J., Cella, M., Colonna, M., Facchetti, F., Günther, G., Johnston, I., Lanzavecchia, A., Nagasaka, T., Okada, T., Vermi, W., Winkels, G., Yamamoto, T., Zysk, M., Yamaguchi, Y., Schmitz, J. J. Exp. Med. (2001) [Pubmed]
  43. Linkage at 12q24 with systemic lupus erythematosus (SLE) is established and confirmed in Hispanic and European American families. Nath, S.K., Quintero-Del-Rio, A.I., Kilpatrick, J., Feo, L., Ballesteros, M., Harley, J.B. Am. J. Hum. Genet. (2004) [Pubmed]
  44. Differential contribution of HLA-DR, DQ, and TAP2 alleles to systemic lupus erythematosus susceptibility in Spanish patients: role of TAP2*01 alleles in Ro autoantibody production. Martín-Villa, J.M., Martínez-Laso, J., Moreno-Pelayo, M.A., Castro-Panete, M.J., Martínez-Quiles, N., Alvarez, M., de Juan, M.D., Gómez-Reino, J.J., Arnaiz-Villena, A. Ann. Rheum. Dis. (1998) [Pubmed]
  45. Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene. Szalai, A.J., McCrory, M.A., Cooper, G.S., Wu, J., Kimberly, R.P. Genes Immun. (2002) [Pubmed]
  46. A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Prokunina, L., Castillejo-López, C., Oberg, F., Gunnarsson, I., Berg, L., Magnusson, V., Brookes, A.J., Tentler, D., Kristjansdóttir, H., Gröndal, G., Bolstad, A.I., Svenungsson, E., Lundberg, I., Sturfelt, G., Jönssen, A., Truedsson, L., Lima, G., Alcocer-Varela, J., Jonsson, R., Gyllensten, U.B., Harley, J.B., Alarcón-Segovia, D., Steinsson, K., Alarcón-Riquelme, M.E. Nat. Genet. (2002) [Pubmed]
  47. Hematopoietic stem-cell transplantation for systemic lupus erythematosus. Burt, R.K., Traynor, A., Ramsey-Goldman, R. N. Engl. J. Med. (1997) [Pubmed]
  48. Radioimmunoassay of the attack complex of complement in serum from patients with systemic lupus erythematosus. Falk, R.J., Dalmasso, A.P., Kim, Y., Lam, S., Michael, A. N. Engl. J. Med. (1985) [Pubmed]
  49. Association between lupus psychosis and anti-ribosomal P protein antibodies. Bonfa, E., Golombek, S.J., Kaufman, L.D., Skelly, S., Weissbach, H., Brot, N., Elkon, K.B. N. Engl. J. Med. (1987) [Pubmed]
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