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MeSH Review

Lupus Nephritis

 
 
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High impact information on Lupus Nephritis

  • In vivo treatment with a monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse [1].
  • Mouse models of lupus-nephritis have been shown to exhibit increased serum BAFF levels correlating with disease severity, and many autoimmune patients were found to have higher levels of circulating BAFF than healthy volunteers [2].
  • In patients with Lupus-nephritis (LN) the increase of activities of urinary GGT, AP, BGRS, NAG, and CHE was observed, the increase was especially clearly shown in LN-patients with NS [3].

References

  1. In vivo treatment with a monoclonal antibody to interferon-gamma neither affects the survival nor the incidence of lupus-nephritis in the MRL/lpr-lpr mouse. Nicoletti, F., Meroni, P., Di Marco, R., Barcellini, W., Borghi, M.O., Gariglio, M., Mattina, A., Grasso, S., Landolfo, S. Immunopharmacology (1992) [Pubmed]
  2. BAFF: B cell survival factor and emerging therapeutic target for autoimmune disorders. Kalled, S.L., Ambrose, C., Hsu, Y.M. Expert Opin. Ther. Targets (2003) [Pubmed]
  3. The significance of the assays of urinary enzymes activity in patients with systemic lupus erythematosus. Delektorskaya, L., Janushkevich, T., Okunev, D. Zeitschrift für medizinische Laboratoriumsdiagnostik. (1990) [Pubmed]
 
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