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Gene Review

Ifng  -  interferon gamma

Mus musculus

Synonyms: IFN-g, IFN-gamma, Ifg, Interferon gamma
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Disease relevance of Ifng


Psychiatry related information on Ifng


High impact information on Ifng


Chemical compound and disease context of Ifng


Biological context of Ifng

Genetic context of IFNg

  • IFNγ level in serum of Leishmania major infected mice is controlled by loci Lmr4 (chromosome 6) [24], Lmr3 (chromosome 5), Lmr5 (chromosome 10) [24], Lmr14 (chromosome 2), Lmr15 (chromosome 11) and Lmr17 (chromosome 9) [25]

Anatomical context of Ifng


Associations of Ifng with chemical compounds

  • In hyperinsulinemic clamp studies, however, Socs1-/- Ifng-/- mice had enhanced hepatic insulin sensitivity demonstrated by greater suppression of endogenous glucose production compared with controls with no difference in glucose disposal [29].
  • Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei [30].
  • In vivo, mice given CT before systemic challenge with lipopolysaccharide had markedly reduced serum levels of IL-12 p40 and interferon gamma [31].
  • Thus, depressed TNF synthesis, diminished expression of CD14, and low plasma LPS-binding capacity, in addition to blocked IFN-gamma signaling in the mutant mice, likely to combine to manifest in the resistant phenotype of IFN gamma R-/- mice to endotoxin [32].
  • Depletion of asialo-GM1+ cells exacerbated infection, though not as much as anti-IFN-gamma mAb [33].
  • IFN-gamma-mediated cardiotoxicity was associated with high-level cardiac transcription of the proinflammatory cytokines tumor necrosis factor-alpha and interleukin-12 and the macrophage-attracting chemokines MCP1 and MIP1-alpha [34].
  • Our data establish possible cross-talk between the adenosine signaling through cAMP and IFN-gamma during regulation of CIITA expression [35].

Physical interactions of Ifng


Enzymatic interactions of Ifng


Regulatory relationships of Ifng


Other interactions of Ifng


Analytical, diagnostic and therapeutic context of Ifng


  1. Differential production of interferon-gamma and interleukin-4 in response to Th1- and Th2-stimulating pathogens by gamma delta T cells in vivo. Ferrick, D.A., Schrenzel, M.D., Mulvania, T., Hsieh, B., Ferlin, W.G., Lepper, H. Nature (1995) [Pubmed]
  2. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. Kamijo, R., Le, J., Shapiro, D., Havell, E.A., Huang, S., Aguet, M., Bosland, M., Vilcek, J. J. Exp. Med. (1993) [Pubmed]
  3. MyD88 primes macrophages for full-scale activation by interferon-gamma yet mediates few responses to Mycobacterium tuberculosis. Shi, S., Nathan, C., Schnappinger, D., Drenkow, J., Fuortes, M., Block, E., Ding, A., Gingeras, T.R., Schoolnik, G., Akira, S., Takeda, K., Ehrt, S. J. Exp. Med. (2003) [Pubmed]
  4. Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. Powrie, F., Correa-Oliveira, R., Mauze, S., Coffman, R.L. J. Exp. Med. (1994) [Pubmed]
  5. Loci controlling lymphocyte production of interferon gamma after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility. Lipoldová, M., Havelková, H., Badalová, J., Vojtíšková, J., Quan, L., Krulová, M., Sohrabi, Y., Stassen, A.P., Demant, P. Cancer. Immunol. Immunother. (2009) [Pubmed]
  6. IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection. Wilson, D.C., Matthews, S., Yap, G.S. J. Immunol. (2008) [Pubmed]
  7. Interferon-gamma targets cancer cells and osteoclasts to prevent tumor-associated bone loss and bone metastases. Xu, Z., Hurchla, M.A., Deng, H., Uluçkan, O., Bu, F., Berdy, A., Eagleton, M.C., Heller, E.A., Floyd, D.H., Dirksen, W.P., Shu, S., Tanaka, Y., Fernandez, S.A., Rosol, T.J., Weilbaecher, K.N. J. Biol. Chem. (2009) [Pubmed]
  8. Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Monsonego, A., Imitola, J., Petrovic, S., Zota, V., Nemirovsky, A., Baron, R., Fisher, Y., Owens, T., Weiner, H.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Accelerated development of neurochemical and behavioral deficits in LP-BM5 infected mice with targeted deletions of the IFN-gamma gene. Koustova, E., Sei, Y., McCarty, T., Espey, M.G., Ming, R., Morse, H.C., Basile, A.S. J. Neuroimmunol. (2000) [Pubmed]
  10. Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines. Kawakami, K., Hossain Qureshi, M., Zhang, T., Koguchi, Y., Xie, Q., Kurimoto, M., Saito, A. Cell. Immunol. (1999) [Pubmed]
  11. Cytokine regulation of lactate dehydrogenase-elevating virus: inhibition of viral replication by interferon-gamma. Cafruny, W.A., Bradley, S.E., Broen, J.J., Wong, G.H. Antiviral Res. (1994) [Pubmed]
  12. Intrapulmonary administration of CCL21 gene-modified dendritic cells reduces tumor burden in spontaneous murine bronchoalveolar cell carcinoma. Yang, S.C., Batra, R.K., Hillinger, S., Reckamp, K.L., Strieter, R.M., Dubinett, S.M., Sharma, S. Cancer Res. (2006) [Pubmed]
  13. Tolerogenic dendritic cells. Steinman, R.M., Hawiger, D., Nussenzweig, M.C. Annu. Rev. Immunol. (2003) [Pubmed]
  14. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., Deretic, V. Cell (2004) [Pubmed]
  15. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Alexander, W.S., Starr, R., Fenner, J.E., Scott, C.L., Handman, E., Sprigg, N.S., Corbin, J.E., Cornish, A.L., Darwiche, R., Owczarek, C.M., Kay, T.W., Nicola, N.A., Hertzog, P.J., Metcalf, D., Hilton, D.J. Cell (1999) [Pubmed]
  16. Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Jin, F.Y., Nathan, C., Radzioch, D., Ding, A. Cell (1997) [Pubmed]
  17. A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production. Neighbors, M., Xu, X., Barrat, F.J., Ruuls, S.R., Churakova, T., Debets, R., Bazan, J.F., Kastelein, R.A., Abrams, J.S., O'Garra, A. J. Exp. Med. (2001) [Pubmed]
  18. STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity. Jeong, W.I., Park, O., Radaeva, S., Gao, B. Hepatology (2006) [Pubmed]
  19. Interferon-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-beta 1, interleukin-1 beta, and interleukin-4 in the heart. Fairweather, D., Frisancho-Kiss, S., Yusung, S.A., Barrett, M.A., Davis, S.E., Gatewood, S.J., Njoku, D.B., Rose, N.R. Am. J. Pathol. (2004) [Pubmed]
  20. IFN-gamma protects cerulein-induced acute pancreatitis by repressing NF-kappa B activation. Hayashi, T., Ishida, Y., Kimura, A., Iwakura, Y., Mukaida, N., Kondo, T. J. Immunol. (2007) [Pubmed]
  21. Long-range histone acetylation of the Ifng gene is an essential feature of T cell differentiation. Zhou, W., Chang, S., Aune, T.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Dynamic alterations in the conformation of the Ifng gene region during T helper cell differentiation. Eivazova, E.R., Aune, T.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  23. The Th1/Th2 balance does not account for the difference of susceptibility of mouse strains to Theiler's virus persistent infection. Monteyne, P., Bihl, F., Levillayer, F., Brahic, M., Bureau, J.F. J. Immunol. (1999) [Pubmed]
  24. Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Lipoldová, M., Svobodová, M., Krulová, M., Havelková, H., Badalová, J., Nohýnková, E., Holán, V., Hart, A.A., Volf, P., Demant, P. Genes. Immun. (2000) [Pubmed]
  25. Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Havelková, H., Badalová, J., Svobodová, M., Vojtíková, J., Kurey, I., Vladimirov, V., Demant, P., Lipoldová, M. Genes. Immun. (2006) [Pubmed]
  26. Histone hyperacetylated domains across the Ifng gene region in natural killer cells and T cells. Chang, S., Aune, T.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  27. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Pernis, A., Gupta, S., Gollob, K.J., Garfein, E., Coffman, R.L., Schindler, C., Rothman, P. Science (1995) [Pubmed]
  28. Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Grewal, I.S., Foellmer, H.G., Grewal, K.D., Xu, J., Hardardottir, F., Baron, J.L., Janeway, C.A., Flavell, R.A. Science (1996) [Pubmed]
  29. Socs1 deficiency enhances hepatic insulin signaling. Jamieson, E., Chong, M.M., Steinberg, G.R., Jovanovska, V., Fam, B.C., Bullen, D.V., Chen, Y., Kemp, B.E., Proietto, J., Kay, T.W., Andrikopoulos, S. J. Biol. Chem. (2005) [Pubmed]
  30. Induction by EGF and interferon-gamma of tyrosine phosphorylated DNA binding proteins in mouse liver nuclei. Ruff-Jamison, S., Chen, K., Cohen, S. Science (1993) [Pubmed]
  31. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor beta1 and beta2 chain expression. Braun, M.C., He, J., Wu, C.Y., Kelsall, B.L. J. Exp. Med. (1999) [Pubmed]
  32. Interferon gamma receptor deficient mice are resistant to endotoxic shock. Car, B.D., Eng, V.M., Schnyder, B., Ozmen, L., Huang, S., Gallay, P., Heumann, D., Aguet, M., Ryffel, B. J. Exp. Med. (1994) [Pubmed]
  33. Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection. Karupiah, G., Blanden, R.V., Ramshaw, I.A. J. Exp. Med. (1990) [Pubmed]
  34. Interferon-gamma induces chronic active myocarditis and cardiomyopathy in transgenic mice. Reifenberg, K., Lehr, H.A., Torzewski, M., Steige, G., Wiese, E., Küpper, I., Becker, C., Ott, S., Nusser, P., Yamamura, K., Rechtsteiner, G., Warger, T., Pautz, A., Kleinert, H., Schmidt, A., Pieske, B., Wenzel, P., Münzel, T., Löhler, J. Am. J. Pathol. (2007) [Pubmed]
  35. Major histocompatibility class II transactivator expression in smooth muscle cells from A2b adenosine receptor knock-out mice: cross-talk between the adenosine and interferon-gamma signaling. Xu, Y., Ravid, K., Smith, B.D. J. Biol. Chem. (2008) [Pubmed]
  36. Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation. Nelson, N., Kanno, Y., Hong, C., Contursi, C., Fujita, T., Fowlkes, B.J., O'Connell, E., Hu-Li, J., Paul, W.E., Jankovic, D., Sher, A.F., Coligan, J.E., Thornton, A., Appella, E., Yang, Y., Ozato, K. J. Immunol. (1996) [Pubmed]
  37. Tumour necrosis factor-alpha and interferon-gamma synergistically activate the RANTES promoter through nuclear factor kappaB and interferon regulatory factor 1 (IRF-1) transcription factors. Lee, A.H., Hong, J.H., Seo, Y.S. Biochem. J. (2000) [Pubmed]
  38. Regulation of murine Tap1 and Lmp2 genes in macrophages by interferon gamma is mediated by STAT1 and IRF-1. Brucet, M., Marqués, L., Sebastián, C., Lloberas, J., Celada, A. Genes Immun. (2004) [Pubmed]
  39. Interferon gamma and antisense transforming growth factor beta transgenes synergize to enhance the immunogenicity of a murine mammary carcinoma. McEarchern, J.A., Besselsen, D.G., Akporiaye, E.T. Cancer Immunol. Immunother. (1999) [Pubmed]
  40. STAT 1 binds to the LPL promoter in vitro. Hogan, J.C., Stephens, J.M. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  41. Activation of the transcription factor ISGF3 by interferon-gamma. Matsumoto, M., Tanaka, N., Harada, H., Kimura, T., Yokochi, T., Kitagawa, M., Schindler, C., Taniguchi, T. Biol. Chem. (1999) [Pubmed]
  42. Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Yoshimoto, T., Bendelac, A., Watson, C., Hu-Li, J., Paul, W.E. Science (1995) [Pubmed]
  43. SOCS3 negatively regulates IL-6 signaling in vivo. Croker, B.A., Krebs, D.L., Zhang, J.G., Wormald, S., Willson, T.A., Stanley, E.G., Robb, L., Greenhalgh, C.J., Förster, I., Clausen, B.E., Nicola, N.A., Metcalf, D., Hilton, D.J., Roberts, A.W., Alexander, W.S. Nat. Immunol. (2003) [Pubmed]
  44. TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. Wesemann, D.R., Qin, H., Kokorina, N., Benveniste, E.N. Nat. Immunol. (2004) [Pubmed]
  45. Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection. Silva, J.S., Morrissey, P.J., Grabstein, K.H., Mohler, K.M., Anderson, D., Reed, S.G. J. Exp. Med. (1992) [Pubmed]
  46. Exacerbation of antigen-induced arthritis in IFN-gamma-deficient mice as a result of unrestricted IL-17 response. Irmler, I.M., Gajda, M., Bräuer, R. J. Immunol. (2007) [Pubmed]
  47. IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. Ramirez-Montagut, T., Chow, A., Kochman, A.A., Smith, O.M., Suh, D., Sindhi, H., Lu, S., Borsotti, C., Grubin, J., Patel, N., Terwey, T.H., Kim, T.D., Heller, G., Murphy, G.F., Liu, C., Alpdogan, O., van den Brink, M.R. J. Immunol. (2007) [Pubmed]
  48. Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Hodge, M.R., Ranger, A.M., Charles de la Brousse, F., Hoey, T., Grusby, M.J., Glimcher, L.H. Immunity (1996) [Pubmed]
  49. Cellular Mechanisms of Fatal Early-Onset Autoimmunity in Mice with the T Cell-Specific Targeting of Transforming Growth Factor-beta Receptor. Marie, J.C., Liggitt, D., Rudensky, A.Y. Immunity (2006) [Pubmed]
  50. ASC/PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. Pedra, J.H., Sutterwala, F.S., Sukumaran, B., Ogura, Y., Qian, F., Montgomery, R.R., Flavell, R.A., Fikrig, E. J. Immunol. (2007) [Pubmed]
  51. T-helper 1-type immunity to trophoblast in women with recurrent spontaneous abortion. Hill, J.A., Polgar, K., Anderson, D.J. JAMA (1995) [Pubmed]
  52. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. Udagawa, N., Horwood, N.J., Elliott, J., Mackay, A., Owens, J., Okamura, H., Kurimoto, M., Chambers, T.J., Martin, T.J., Gillespie, M.T. J. Exp. Med. (1997) [Pubmed]
  53. Interleukin-10 is a natural suppressor of cytokine production and inflammation in a murine model of allergic bronchopulmonary aspergillosis. Grünig, G., Corry, D.B., Leach, M.W., Seymour, B.W., Kurup, V.P., Rennick, D.M. J. Exp. Med. (1997) [Pubmed]
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