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MeSH Review

Drug Contamination

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High impact information on Drug Contamination

  • Overall, the system features are very favorable for applications such as drug impurity profiling as is illustrated by the analysis of mebeverine and related compounds (both charged and neutral) at the 0.25% (w/w) level [1].
  • The rationale supporting the presence and determination of processing impurities/by-products in cocaine samples is discussed, and chromatographic methodology used for the development of drug impurity signature profiles is presented [2].
  • Analysis of drug contamination from parabens in theophylline olamine [3].
  • Proper disposal of urinary products of MPTP-treated animals is therefore necessary to reduce the risk of possible drug contamination in humans [4].
  • The usefulness of applying an integrated LC-NMR and LC-MS approach to acarbose bulk drug impurity profiling is demonstrated [5].


  1. Atmospheric pressure photoionization for enhanced compatibility in on-line micellar electrokinetic chromatography-mass spectrometry. Mol, R., de Jong, G.J., Somsen, G.W. Anal. Chem. (2005) [Pubmed]
  2. In-depth chromatographic analyses of illicit cocaine and its precursor, coca leaves. Moore, J.M., Casale, J.F. Journal of chromatography. A. (1994) [Pubmed]
  3. Analysis of drug contamination from parabens in theophylline olamine. Juenge, E.C., Gurka, D.F., Kreienbaum, M.A. Journal of pharmaceutical sciences. (1981) [Pubmed]
  4. MPTP in mice: treatment, distribution and possible source of contamination. Crampton, J.M., Runice, C.E., Doyle, T.J., Lau, Y.S., Wilson, J.A. Life Sci. (1988) [Pubmed]
  5. Identification of impurities in acarbose by using an integrated liquid chromatography-nuclear magnetic resonance and liquid chromatography-mass spectrometry approach. Novak, P., Cindrić, M., Tepes, P., Dragojević, S., Ilijas, M., Mihaljević, K. Journal of separation science. (2005) [Pubmed]
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