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Chemical Compound Review

colamine     2-aminoethanol

Synonyms: Glycinol, Kolamin, Olamine, Olaminl, Etanolamina, ...
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Disease relevance of colamine


Psychiatry related information on colamine


High impact information on colamine


Chemical compound and disease context of colamine


Biological context of colamine

  • Lysis of pneumococci by the surfactant fraction appeared to be mediated by a detergent-like activation of pneumococcal autolysin, in that bacteriolysis was prevented by substitution of ethanolamine for choline in pneumococcal cell walls, and a pneumococcal transformant that lacked autolysin was not lysed [19].
  • A specific function of inositol acylation in trypanosomes may be to enhance the efficiency of ethanolamine phosphate addition to the Man3GlcN-(acyl)PI intermediate [20].
  • Addition of PE or ethanolamine, a precursor of PE synthesis, restored the cell surface PE on the cleavage furrow and normal cytokinesis [21].
  • Evaluation of the cells' energetics indicated that the enhanced production of phosphoethanolamine is probably not due to ethanolamine phosphorylation [22].
  • In addition, both BGTC and BGSC present also a high transfection activity when formulated as liposomes with the neutral phospholipid dioleoylphosphatidyl ethanolamine [23].

Anatomical context of colamine

  • The surfactant fraction readily killed pneumococci containing ethanolamine or the autolysin-defective transformant, and studies with tritiated methyl-D-glucose loading and release showed that killing was associated with increased bacterial cell membrane permeability [19].
  • Compared with the normal erythrocyte, the outer membrane leaflet of the deoxygenated, reversibly sickled cells (RSC) and irreversibly sickled cells (ISC) was enriched in phosphatidyl ethanolamine in addition to containing phosphatidyl serine [24].
  • Duodenal ulcerogens, unlike the nonulcerogen but toxic analogue ethanolamine, caused an early disruption of the myoelectric migrating complex, a marked increase in the spiking activity, and a decrease in the frequency of the slow waves in the duodenum [25].
  • The glycosomes were surrounded by a single membrane and contained as phospholipids only phosphatidyl choline and phosphatidyl ethanolamine in a ratio of 2:1 [26].
  • Ethanolamine modulates the rate of rat hepatocyte proliferation in vitro and in vivo [3].

Associations of colamine with other chemical compounds


Gene context of colamine


Analytical, diagnostic and therapeutic context of colamine


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  2. Evidence for the B12-dependent enzyme ethanolamine deaminase in Salmonella. Chang, G.W., Chang, J.T. Nature (1975) [Pubmed]
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  17. Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy. Daly, P.F., Lyon, R.C., Faustino, P.J., Cohen, J.S. J. Biol. Chem. (1987) [Pubmed]
  18. Global regulation by CsrA in Salmonella typhimurium. Lawhon, S.D., Frye, J.G., Suyemoto, M., Porwollik, S., McClelland, M., Altier, C. Mol. Microbiol. (2003) [Pubmed]
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  21. An essential role for a membrane lipid in cytokinesis. Regulation of contractile ring disassembly by redistribution of phosphatidylethanolamine. Emoto, K., Umeda, M. J. Cell Biol. (2000) [Pubmed]
  22. Stimulation of cAMP and phosphomonoester production by melanotropin in melanoma cells: 31P NMR studies. Degani, H., DeJordy, J.O., Salomon, Y. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Guanidinium-cholesterol cationic lipids: efficient vectors for the transfection of eukaryotic cells. Vigneron, J.P., Oudrhiri, N., Fauquet, M., Vergely, L., Bradley, J.C., Basseville, M., Lehn, P., Lehn, J.M. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. Abnormalities in membrane phospholipid organization in sickled erythrocytes. Lubin, B., Chiu, D., Bastacky, J., Roelofsen, B., Van Deenen, L.L. J. Clin. Invest. (1981) [Pubmed]
  25. Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Pihan, G., Kline, T.J., Hollenberg, N.K., Szabo, S. Gastroenterology (1985) [Pubmed]
  26. Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei. Opperdoes, F.R., Baudhuin, P., Coppens, I., De Roe, C., Edwards, S.W., Weijers, P.J., Misset, O. J. Cell Biol. (1984) [Pubmed]
  27. Phospholipase C release of basic fibroblast growth factor from human bone marrow cultures as a biologically active complex with a phosphatidylinositol-anchored heparan sulfate proteoglycan. Brunner, G., Gabrilove, J., Rifkin, D.B., Wilson, E.L. J. Cell Biol. (1991) [Pubmed]
  28. Carcinoembryonic antigen is anchored to membranes by covalent attachment to a glycosylphosphatidylinositol moiety: identification of the ethanolamine linkage site. Hefta, S.A., Hefta, L.J., Lee, T.D., Paxton, R.J., Shively, J.E. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
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  31. Specific pools of phospholipids are used for lipoprotein secretion by cultured rat hepatocytes. Vance, J.E., Vance, D.E. J. Biol. Chem. (1986) [Pubmed]
  32. sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases in Saccharomyces cerevisiae. Nucleotide sequence of the EPT1 gene and comparison of the CPT1 and EPT1 gene products. Hjelmstad, R.H., Bell, R.M. J. Biol. Chem. (1991) [Pubmed]
  33. Phosphatidylserine decarboxylase 2 of Saccharomyces cerevisiáe. Cloning and mapping of the gene, heterologous expression, and creation of the null allele. Trotter, P.J., Pedretti, J., Yates, R., Voelker, D.R. J. Biol. Chem. (1995) [Pubmed]
  34. Glycosylphosphatidylinositol (GPI) proteins of Saccharomyces cerevisiae contain ethanolamine phosphate groups on the alpha1,4-linked mannose of the GPI anchor. Imhof, I., Flury, I., Vionnet, C., Roubaty, C., Egger, D., Conzelmann, A. J. Biol. Chem. (2004) [Pubmed]
  35. Phosphatidylethanolamine is the donor of the ethanolamine residue linking a glycosylphosphatidylinositol anchor to protein. Menon, A.K., Stevens, V.L. J. Biol. Chem. (1992) [Pubmed]
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  38. Regulation of the cytidine phospholipid pathways in human cancer cells and effects of 1-beta-D-arabinofuranosylcytosine: a noninvasive 31P nuclear magnetic resonance study. Daly, P.F., Zugmaier, G., Sandler, D., Carpen, M., Myers, C.E., Cohen, J.S. Cancer Res. (1990) [Pubmed]
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  40. [3H]myoinositol incorporation into phospholipids in liver microsomes from humans with and without type II diabetes. The lack of synthesis of glycosylphosphatidylinositol, precursor of the insulin mediator inositol phosphate glycan. Thakkar, J.K., Raju, M.S., Kennington, A.S., Foil, B., Caro, J.F. J. Biol. Chem. (1990) [Pubmed]
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