The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Mebeverina     4-[ethyl-[1-(4- methoxyphenyl)propan-2...

Synonyms: mebeverine, Arluy, Mebeverinum, CAT-354, SureCN25804, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Csag-144


Psychiatry related information on Csag-144

  • Human motor activity in the small bowel is more reproducible than that in the large bowel; therefore the aim of this study was to determine in the small bowel the effects of oral mebeverine in both IBS patients and in healthy controls [4].

High impact information on Csag-144


Chemical compound and disease context of Csag-144


Biological context of Csag-144

  • The results show that mebeverine undergoes rapid and extensive first-pass metabolism involving hydrolysis of the ester function, and that negligible circulating concentrations of the parent drug are found in humans [12].
  • The hyperpolarization induced by a second addition of adrenaline to the preparation was decreased and sustained in the presence of mebeverine, while the decrease of the electrotonic potential evoked during the alpha 1 response was less pronounced [13].
  • However, when administered i.v. but not i.j., the doses of mebeverine that inhibited jejunal motility also significantly reduced heart rate and arterial blood pressure [8].
  • The amplitude and duration of the compound action potential evoked in the vagus nerve were decreased by mebeverine but not by the metabolites [14].
  • In conclusion, the results confirm in vivo the antispasmodic effect of mebeverine and suggested that mebeverine can influence epithelial transport, probably in the direction of enhanced intestinal absorption [8].

Anatomical context of Csag-144

  • Hyperpolarization and cessation of spike activity of the muscle cells, accompanied by an increased amplitude of the electrotonic potential were observed in the presence of mebeverine (6 X 10(-5] after block of the alpha 2-, beta- and muscarinic receptors [13].
  • On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine [15].
  • Cisapride and mebeverine were more effective per given concentration, when delivered IL than IA in both the ileum and sigmoid colon preparations [16].

Associations of Csag-144 with other chemical compounds


Gene context of Csag-144

  • Mebeverine bound to beta 2- and alpha-receptors and inhibited phosphodiesterase activity and calcium accumulation [21].

Analytical, diagnostic and therapeutic context of Csag-144


  1. Mebeverine-induced perforated colon in distal intestinal syndrome of cystic fibrosis. Hassan, W., Keaney, N. Lancet (1990) [Pubmed]
  2. Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients. Jones, R.H., Holtmann, G., Rodrigo, L., Ehsanullah, R.S., Crompton, P.M., Jacques, L.A., Mills, J.G. Aliment. Pharmacol. Ther. (1999) [Pubmed]
  3. Drug therapy options for patients with irritable bowel syndrome. Talley, N.J. The American journal of managed care. (2001) [Pubmed]
  4. Mebeverine alters small bowel motility in irritable bowel syndrome. Evans, P.R., Bak, Y.T., Kellow, J.E. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  5. Atmospheric pressure photoionization for enhanced compatibility in on-line micellar electrokinetic chromatography-mass spectrometry. Mol, R., de Jong, G.J., Somsen, G.W. Anal. Chem. (2005) [Pubmed]
  6. Mebeverine decreases mass movements and stool frequency in lactulose-induced diarrhoea. Washington, N., Ridley, P., Thomas, C., Spiller, R.C., Watts, P.J., Wilson, C.G. Aliment. Pharmacol. Ther. (1998) [Pubmed]
  7. Meta-analysis of smooth muscle relaxants in the treatment of irritable bowel syndrome. Poynard, T., Naveau, S., Mory, B., Chaput, J.C. Aliment. Pharmacol. Ther. (1994) [Pubmed]
  8. Effect of mebeverine hydrochloride on jejunal motility and epithelial transport in the anesthetized ferret. Greenwood, B., Mandel, K.G. Eur. J. Pharmacol. (1992) [Pubmed]
  9. Alosetron. Mucke, H., Cole, P., Rabasseda, X. Drugs of today (Barcelona, Spain : 1998) (2000) [Pubmed]
  10. A randomised, double-blind study of mebeverine versus dicyclomine in the treatment of functional abdominal pain in young adults. Grillage, M.G., Nankani, J.N., Atkinson, S.N., Prescott, P. The British journal of clinical practice. (1990) [Pubmed]
  11. Comparison of two different formulations of mebeverine hydrochloride in irritable bowel syndrome. Gilbody, J.S., Fletcher, C.P., Hughes, I.W., Kidman, S.P. International journal of clinical practice. (2000) [Pubmed]
  12. Facile hydrolysis of mebeverine in vitro and in vivo: negligible circulating concentrations of the drug after oral administration. Dickinson, R.G., Baker, P.V., Franklin, M.E., Hooper, W.D. Journal of pharmaceutical sciences. (1991) [Pubmed]
  13. Modification of alpha 1-receptor-operated channels by mebeverine in smooth muscle cells of guinea-pig taenia caeci. Den Hertog, A., Van den Akker, J. Eur. J. Pharmacol. (1987) [Pubmed]
  14. The action of mebeverine and metabolites on mammalian non-myelinated nerve fibres. Den Hertog, A., Van den Akker, J. Eur. J. Pharmacol. (1987) [Pubmed]
  15. On the metabolism of the amphetamine-derived antispasmodic drug mebeverine: gas chromatography-mass spectrometry studies on rat liver microsomes and on human urine. Kraemer, T., Bickeboeller-Friedrich, J., Maurer, H.H. Drug Metab. Dispos. (2000) [Pubmed]
  16. Direct mucosal targeting of colonic receptors by prokinetic drugs in an experimental model. Ho, Y.H., Evans, D.F., Hardcastle, J.D. Ann. Acad. Med. Singap. (1999) [Pubmed]
  17. On-line micellar electrokinetic chromatography-mass spectrometry: feasibility of direct introduction of non-volatile buffer and surfactant into the electrospray interface. Somsen, G.W., Mol, R., de Jong, G.J. Journal of chromatography. A. (2003) [Pubmed]
  18. Identification of mebeverine acid as the main circulating metabolite of mebeverine in man. Stockis, A., Guelen, P.J., de Vos, D. Journal of pharmaceutical and biomedical analysis. (2002) [Pubmed]
  19. Mebeverine influences sodium ion transport in the distal colon. Tyrakowski, T., M??odzik-Danielewicz, N., Kurek, W., Szaflarska-Pop??awska, A., Czerwionka-Szaflarska, M., Kapa??a, A., Kopczy??ska, E., Ho??y??ska, I., Kaczorowski, P. Pharmacological reports : PR (2006) [Pubmed]
  20. A double-blind placebo-controlled crossover study of mebeverine and mefenamic acid in the treatment of primary dysmenorrhoea. Langrick, A.F., Gunn, A.D., Livesey, H., Whitehead, A.M. The British journal of clinical practice. (1989) [Pubmed]
  21. Heterogeneity of biochemical actions among vasodilators. Greenslade, F.C., Scott, C.K., Newquist, K.L., Krider, K.M., Chasin, M. Journal of pharmaceutical sciences. (1982) [Pubmed]
  22. Development of a standardized analysis strategy for basic drugs using ion-pair extraction and high-performance liquid chromatography. VIII. Method construction for the determination of mebeverine in tablets and biological fluids. Hoogewijs, G., Massart, D.L. J. Chromatogr. (1986) [Pubmed]
  23. Evaluation of capillary supercritical fluid chromatography with mass spectrometric detection for the analysis of a drug (mebeverine) in a dog plasma matrix. Pinkston, J.D., Venkatramani, C.J., Tulich, L.J., Bowling, D.J., Wehmeyer, K.R. J. Chromatogr. (1993) [Pubmed]
  24. Treatment patterns and health care costs of mebeverine-treated IBS patients: a case-control study. Goettsch, W.G., van den Boom, G., Breekveldt-Postma, N.S., Smout, A.J., Herings, R.M. Pharmacoepidemiology and drug safety. (2004) [Pubmed]
  25. Effect of a calcium channel blocker and antispasmodic in diarrhoea-predominant irritable bowel syndrome. Lu, C.L., Chen, C.Y., Chang, F.Y., Chang, S.S., Kang, L.J., Lu, R.H., Lee, S.D. J. Gastroenterol. Hepatol. (2000) [Pubmed]
WikiGenes - Universities