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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.

The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.[1]

References

  1. Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits. Callender, D.P., Jayaprakash, N., Bell, A., Petraitis, V., Petraitiene, R., Candelario, M., Schaufele, R., Dunn, J.M., Sei, S., Walsh, T.J., Balis, F.M., Petratienes, R. Antimicrob. Agents Chemother. (1999) [Pubmed]
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