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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2'-deoxyadenosine.

A few cases of secondary neoplasms occurring after treatment with 2-chloro-2'-deoxyadenosine (2CdA) have been reported, mostly in patients previously exposed to other anti-cancer drugs including alkylating agents (AA). Here we report on the occurrence of a myelodysplastic syndrome (MDS) with monosomy 5 and/or 7 in two patients after 2CdA treatment, without or prior to other toxic exposure. In light of a literature review and given the involvement of chromosomes frequently abnormal in secondary leukaemias, we suggest that 2CdA may induce therapy-related MDS (t-MDS).[1]


  1. Myelodysplastic syndrome with monosomy 5 and/or 7 following therapy with 2-chloro-2'-deoxyadenosine. Van Den Neste, E., Louviaux, I., Michaux, J.L., Delannoy, A., Michaux, L., Hagemeijer, A., Scheiff, J.M., Bosly, A., Straetmans, N., Ferrant, A. Br. J. Haematol. (1999) [Pubmed]
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