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Chemical Compound Review

Leustatin     (2R,3S,5R)-5-(6-amino-2- chloro-purin-9-yl)...

Synonyms: Movectro, Leustat, Mylinax, Cladribine, CldAdo, ...
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Disease relevance of Leustatin


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Chemical compound and disease context of Leustatin


Biological context of Leustatin


Anatomical context of Leustatin


Associations of Leustatin with other chemical compounds


Gene context of Leustatin


Analytical, diagnostic and therapeutic context of Leustatin


  1. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. Piro, L.D., Carrera, C.J., Carson, D.A., Beutler, E. N. Engl. J. Med. (1990) [Pubmed]
  2. 2-Chlorodeoxyadenosine therapy in chronic lymphocytic leukemia. Saven, A., Piro, L. N. Engl. J. Med. (1994) [Pubmed]
  3. Epstein-Barr virus-associated lymphoma after treatment of macroglobulinemia with cladribine. Niesvizky, R., Zhu, A.X., Louie, D., Michaeli, J. N. Engl. J. Med. (1999) [Pubmed]
  4. Treatment of systemic mast-cell disease with cladribine. Tefferi, A., Li, C.Y., Butterfield, J.H., Hoagland, H.C. N. Engl. J. Med. (2001) [Pubmed]
  5. Tumor lysis syndrome after treatment of chronic lymphocytic leukemia with cladribine. Trendle, M.C., Tefferi, A. N. Engl. J. Med. (1994) [Pubmed]
  6. Lack of effect of 2-chlorodeoxyadenosine therapy in patients with chronic lymphocytic leukemia refractory to fludarabine therapy. O'Brien, S., Kantarjian, H., Estey, E., Koller, C., Robertson, B., Beran, M., Andreeff, M., Pierce, S., Keating, M. N. Engl. J. Med. (1994) [Pubmed]
  7. Brief report: tumor lysis syndrome following treatment with 2-chlorodeoxyadenosine for refractory chronic lymphocytic leukemia. Dann, E.J., Gillis, S., Polliack, A., Okon, E., Rund, D., Rachmilewitz, E.A. N. Engl. J. Med. (1993) [Pubmed]
  8. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. Seto, S., Carrera, C.J., Kubota, M., Wasson, D.B., Carson, D.A. J. Clin. Invest. (1985) [Pubmed]
  9. Eradication of minimal residual disease in hairy cell leukemia. Ravandi, F., Jorgensen, J.L., O'Brien, S.M., Verstovsek, S., Koller, C.A., Faderl, S., Giles, F.J., Ferrajoli, A., Wierda, W.G., Odinga, S., Huang, X., Thomas, D.A., Freireich, E.J., Jones, D., Keating, M.J., Kantarjian, H.M. Blood (2006) [Pubmed]
  10. Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG CLL2). Robak, T., Blonski, J.Z., Gora-Tybor, J., Jamroziak, K., Dwilewicz-Trojaczek, J., Tomaszewska, A., Konopka, L., Ceglarek, B., Dmoszynska, A., Kowal, M., Kloczko, J., Stella-Holowiecka, B., Sulek, K., Calbecka, M., Zawilska, K., Kuliczkowski, K., Skotnicki, A.B., Warzocha, K., Kasznicki, M. Blood (2006) [Pubmed]
  11. Therapeutic and neurotoxic effects of 2-chlorodeoxyadenosine in adults with acute myeloid leukemia. Vahdat, L., Wong, E.T., Wile, M.J., Rosenblum, M., Foley, K.M., Warrell, R.P. Blood (1994) [Pubmed]
  12. 2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent lymphoid malignancies. Saven, A., Piro, L.D. Ann. Intern. Med. (1994) [Pubmed]
  13. Induction of an apoptotic program in cell-free extracts by 2-chloro-2'-deoxyadenosine 5'-triphosphate and cytochrome c. Leoni, L.M., Chao, Q., Cottam, H.B., Genini, D., Rosenbach, M., Carrera, C.J., Budihardjo, I., Wang, X., Carson, D.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  14. 2-chlorodeoxyadenosine induces durable remissions and prolonged suppression of CD4+ lymphocyte counts in patients with hairy cell leukemia. Seymour, J.F., Kurzrock, R., Freireich, E.J., Estey, E.H. Blood (1994) [Pubmed]
  15. Flow cytometry of blood and bone marrow cells from patients with hairy cell leukemia: phenotype of hairy cells and lymphocyte subsets after treatment with 2-chlorodeoxyadenosine. Juliusson, G., Lenkei, R., Liliemark, J. Blood (1994) [Pubmed]
  16. Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine. Juliusson, G., Elmhorn-Rosenborg, A., Liliemark, J. N. Engl. J. Med. (1992) [Pubmed]
  17. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy. Carrera, C.J., Terai, C., Lotz, M., Curd, J.G., Piro, L.D., Beutler, E., Carson, D.A. J. Clin. Invest. (1990) [Pubmed]
  18. Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium. Brown, G.R., Thiele, D.L., Silva, M., Beutler, B. Gastroenterology (1997) [Pubmed]
  19. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine. Carson, D.A., Wasson, D.B., Esparza, L.M., Carrera, C.J., Kipps, T.J., Cottam, H.B. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  20. 2-Chlorodeoxyadenosine therapy in patients with T-cell lymphoproliferative disorders. O'Brien, S., Kurzrock, R., Duvic, M., Kantarjian, H., Stass, S., Robertson, L.E., Estey, E., Pierce, S., Keating, M.J. Blood (1994) [Pubmed]
  21. Second malignancies in patients with hairy cell leukemia in british columbia: a 20-year experience. Au, W.Y., Klasa, R.J., Gallagher, R., Le, N., Gascoyne, R.D., Connors, J.M. Blood (1998) [Pubmed]
  22. PKC412 inhibits in vitro growth of neoplastic human mast cells expressing the D816V-mutated variant of KIT: comparison with AMN107, imatinib, and cladribine (2CdA) and evaluation of cooperative drug effects. Gleixner, K.V., Mayerhofer, M., Aichberger, K.J., Derdak, S., Sonneck, K., Böhm, A., Gruze, A., Samorapoompichit, P., Manley, P.W., Fabbro, D., Pickl, W.F., Sillaber, C., Valent, P. Blood (2006) [Pubmed]
  23. Bcl-2 relieves deoxyadenylate stress and suppresses apoptosis in pre-B leukemia cells. Gao, X., Knudsen, T.B., Ibrahim, M.M., Haldar, S. Cell Death Differ. (1995) [Pubmed]
  24. Second cancer risk in hairy cell leukemia: analysis of 350 patients. Kurzrock, R., Strom, S.S., Estey, E., O'Brien, S., Keating, M.J., Jiang, H., Adams, T., Talpaz, M. J. Clin. Oncol. (1997) [Pubmed]
  25. Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway. Klöpfer, A., Hasenjäger, A., Belka, C., Schulze-Osthoff, K., Dörken, B., Daniel, P.T. Oncogene (2004) [Pubmed]
  26. Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Reid, G., Wielinga, P., Zelcer, N., De Haas, M., Van Deemter, L., Wijnholds, J., Balzarini, J., Borst, P. Mol. Pharmacol. (2003) [Pubmed]
  27. Expression and release of chemokines associated with apoptotic cell death in human promonocytic U937 cells and peripheral blood mononuclear cells. Mühl, H., Nold, M., Chang, J.H., Frank, S., Eberhardt, W., Pfeilschifter, J. Eur. J. Immunol. (1999) [Pubmed]
  28. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Gerstin, K.M., Dresser, M.J., Giacomini, K.M. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  29. Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB. Smal, C., Lisart, S., Maerevoet, M., Ferrant, A., Bontemps, F., Van Den Neste, E. Biochem. Pharmacol. (2007) [Pubmed]
  30. Treatment of Waldenstrom macroglobulinemia with 2-chlorodeoxyadenosine. Dimopoulos, M.A., Kantarjian, H., Estey, E., O'Brien, S., Delasalle, K., Keating, M.J., Freireich, E.J., Alexanian, R. Ann. Intern. Med. (1993) [Pubmed]
  31. The treatment of chronic progressive multiple sclerosis with cladribine. Beutler, E., Sipe, J.C., Romine, J.S., Koziol, J.A., McMillan, R., Zyroff, J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  32. Responses in refractory hairy cell leukemia to a recombinant immunotoxin. Kreitman, R.J., Wilson, W.H., Robbins, D., Margulies, I., Stetler-Stevenson, M., Waldmann, T.A., Pastan, I. Blood (1999) [Pubmed]
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