Coactivator and corepressor complexes in nuclear receptor function.
The nuclear hormone receptors constitute a large family of transcription factors. The binding of the hormonal ligands induces nuclear receptors to assume a configuration that leads to transcriptional activation. Recent studies of retinoic acid and thyroid hormone receptors revealed that, upon ligand binding, a histone deacetylase (HDAC)-containing complex is displaced from the nuclear receptor in exchange for a histone acetyltransferase (HAT)-containing complex. These observations suggest that ligand-dependent recruitment of chromatin-remodeling activity serves as a general mechanism underlying the switch of nuclear receptors from being transcriptionally repressive to being transcriptionally active.[1]References
- Coactivator and corepressor complexes in nuclear receptor function. Xu, L., Glass, C.K., Rosenfeld, M.G. Curr. Opin. Genet. Dev. (1999) [Pubmed]
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