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Gene Review

HAT1  -  histone acetyltransferase 1

Homo sapiens

Synonyms: Histone acetyltransferase 1, Histone acetyltransferase type B catalytic subunit, KAT1
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Disease relevance of HAT1


High impact information on HAT1


Chemical compound and disease context of HAT1


Biological context of HAT1


Anatomical context of HAT1


Associations of HAT1 with chemical compounds


Physical interactions of HAT1


Regulatory relationships of HAT1


Other interactions of HAT1


Analytical, diagnostic and therapeutic context of HAT1


  1. Histone acetyltransferase (HAT) activity of p300 modulates human T lymphotropic virus type 1 p30(II)-mediated repression of LTR transcriptional activity. Michael, B., Nair, A.M., Datta, A., Hiraragi, H., Ratner, L., Lairmore, M.D. Virology (2006) [Pubmed]
  2. Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Palhan, V.B., Chen, S., Peng, G.H., Tjernberg, A., Gamper, A.M., Fan, Y., Chait, B.T., La Spada, A.R., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome. Murata, T., Kurokawa, R., Krones, A., Tatsumi, K., Ishii, M., Taki, T., Masuno, M., Ohashi, H., Yanagisawa, M., Rosenfeld, M.G., Glass, C.K., Hayashi, Y. Hum. Mol. Genet. (2001) [Pubmed]
  4. E1A12S-mediated activation of the adenovirus type 12 E2 promoter depends on the histone acetyltransferase activity of p300/CBP. Fax, P., Lehmkuhler, O., Kuhn, C., Esche, H., Brockmann, D. J. Biol. Chem. (2000) [Pubmed]
  5. Transcriptional regulation of the transforming growth factor beta type II receptor gene by histone acetyltransferase and deacetylase is mediated by NF-Y in human breast cancer cells. Park, S.H., Lee, S.R., Kim, B.C., Cho, E.A., Patel, S.P., Kang, H.B., Sausville, E.A., Nakanishi, O., Trepel, J.B., Lee, B.I., Kim, S.J. J. Biol. Chem. (2002) [Pubmed]
  6. A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Kang, J., Shi, Y., Xiang, B., Qu, B., Su, W., Zhu, M., Zhang, M., Bao, G., Wang, F., Zhang, X., Yang, R., Fan, F., Chen, X., Pei, G., Ma, L. Cell (2005) [Pubmed]
  7. Mutations truncating the EP300 acetylase in human cancers. Gayther, S.A., Batley, S.J., Linger, L., Bannister, A., Thorpe, K., Chin, S.F., Daigo, Y., Russell, P., Wilson, A., Sowter, H.M., Delhanty, J.D., Ponder, B.A., Kouzarides, T., Caldas, C. Nat. Genet. (2000) [Pubmed]
  8. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Chen, H., Lin, R.J., Schiltz, R.L., Chakravarti, D., Nash, A., Nagy, L., Privalsky, M.L., Nakatani, Y., Evans, R.M. Cell (1997) [Pubmed]
  9. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Mizzen, C.A., Yang, X.J., Kokubo, T., Brownell, J.E., Bannister, A.J., Owen-Hughes, T., Workman, J., Wang, L., Berger, S.L., Kouzarides, T., Nakatani, Y., Allis, C.D. Cell (1996) [Pubmed]
  10. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., Nakatani, Y. Cell (1996) [Pubmed]
  11. Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. Lubenow, N., Eichler, P., Lietz, T., Greinacher, A. J. Thromb. Haemost. (2005) [Pubmed]
  12. Chromatin assembly: biochemical identities and genetic redundancy. Adams, C.R., Kamakaka, R.T. Curr. Opin. Genet. Dev. (1999) [Pubmed]
  13. RPD3-type histone deacetylases in maize embryos. Lechner, T., Lusser, A., Pipal, A., Brosch, G., Loidl, A., Goralik-Schramel, M., Sendra, R., Wegener, S., Walton, J.D., Loidl, P. Biochemistry (2000) [Pubmed]
  14. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Ito, K., Barnes, P.J., Adcock, I.M. Mol. Cell. Biol. (2000) [Pubmed]
  15. Effects of acetylation of histone H4 at lysines 8 and 16 on activity of the Hat1 histone acetyltransferase. Makowski, A.M., Dutnall, R.N., Annunziato, A.T. J. Biol. Chem. (2001) [Pubmed]
  16. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Verreault, A., Kaufman, P.D., Kobayashi, R., Stillman, B. Curr. Biol. (1998) [Pubmed]
  17. Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment. Smith, J.L., Freebern, W.J., Collins, I., De Siervi, A., Montano, I., Haggerty, C.M., McNutt, M.C., Butscher, W.G., Dzekunova, I., Petersen, D.W., Kawasaki, E., Merchant, J.L., Gardner, K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  18. moz regulates Hox expression and pharyngeal segmental identity in zebrafish. Miller, C.T., Maves, L., Kimmel, C.B. Development (2004) [Pubmed]
  19. Small-molecule inhibitors of histone acetyltransferase activity: identification and biological properties. Mai, A., Rotili, D., Tarantino, D., Ornaghi, P., Tosi, F., Vicidomini, C., Sbardella, G., Nebbioso, A., Miceli, M., Altucci, L., Filetici, P. J. Med. Chem. (2006) [Pubmed]
  20. Efflux of depsipeptide FK228 (FR901228, NSC-630176) is mediated by P-glycoprotein and multidrug resistance-associated protein 1. Xiao, J.J., Foraker, A.B., Swaan, P.W., Liu, S., Huang, Y., Dai, Z., Chen, J., Sadée, W., Byrd, J., Marcucci, G., Chan, K.K. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  21. Multiple functions of dynamic histone acetylation. Davie, J.R., Hendzel, M.J. J. Cell. Biochem. (1994) [Pubmed]
  22. Histone acetyltransferase p300 regulates the transcription of human erythroid-specific 5-aminolevulinate synthase gene. Han, L., Lu, J., Pan, L., Wang, X., Shao, Y., Han, S., Huang, B. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. Histone acetyltransferase 1 is dispensable for replication-coupled chromatin assembly but contributes to recover DNA damages created following replication blockage in vertebrate cells. Barman, H.K., Takami, Y., Ono, T., Nishijima, H., Sanematsu, F., Shibahara, K., Nakayama, T. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  24. Coactivator and corepressor complexes in nuclear receptor function. Xu, L., Glass, C.K., Rosenfeld, M.G. Curr. Opin. Genet. Dev. (1999) [Pubmed]
  25. Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression. Choy, J.S., Tobe, B.T., Huh, J.H., Kron, S.J. J. Biol. Chem. (2001) [Pubmed]
  26. Histone deacetylation inhibits IL4 gene expression in T cells. Valapour, M., Guo, J., Schroeder, J.T., Keen, J., Cianferoni, A., Casolaro, V., Georas, S.N. J. Allergy Clin. Immunol. (2002) [Pubmed]
  27. Acetylation of cAMP-responsive element-binding protein (CREB) by CREB-binding protein enhances CREB-dependent transcription. Lu, Q., Hutchins, A.E., Doyle, C.M., Lundblad, J.R., Kwok, R.P. J. Biol. Chem. (2003) [Pubmed]
  28. P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. Huang, S., Qiu, Y., Shi, Y., Xu, Z., Brandt, S.J. EMBO J. (2000) [Pubmed]
  29. Acetylation by histone acetyltransferase CREB-binding protein/p300 of STAT6 is required for transcriptional activation of the 15-lipoxygenase-1 gene. Shankaranarayanan, P., Chaitidis, P., Kühn, H., Nigam, S. J. Biol. Chem. (2001) [Pubmed]
  30. Conditional modulation of glucocorticoid receptor activities by CREB-binding protein (CBP) and p300. Kino, T., Nordeen, S.K., Chrousos, G.P. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  31. PCAF interacts with tax and stimulates tax transactivation in a histone acetyltransferase-independent manner. Jiang, H., Lu, H., Schiltz, R.L., Pise-Masison, C.A., Ogryzko, V.V., Nakatani, Y., Brady, J.N. Mol. Cell. Biol. (1999) [Pubmed]
  32. Regulation of human SRY subcellular distribution by its acetylation/deacetylation. Thevenet, L., Méjean, C., Moniot, B., Bonneaud, N., Galéotti, N., Aldrian-Herrada, G., Poulat, F., Berta, P., Benkirane, M., Boizet-Bonhoure, B. EMBO J. (2004) [Pubmed]
  33. Histone acetyltransferase activity of p300 enhances the activation of IL-12 p40 promoter. Sun, H., Lu, J., Wei, L., Wang, X., Xu, X., Dong, M., Huang, B. Mol. Immunol. (2004) [Pubmed]
  34. Histone acetyltransferase p300 promotes the activation of human WT1 promoter and intronic enhancer. Shao, Y., Lu, J., Zhang, G., Liu, C., Huang, B. Arch. Biochem. Biophys. (2005) [Pubmed]
  35. Steroid receptor induction of gene transcription: a two-step model. Jenster, G., Spencer, T.E., Burcin, M.M., Tsai, S.Y., Tsai, M.J., O'Malley, B.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  36. Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases. Wong, K., Zhang, J., Awasthi, S., Sharma, A., Rogers, L., Matlock, E.F., Van Lint, C., Karpova, T., McNally, J., Harrod, R. J. Biol. Chem. (2004) [Pubmed]
  37. SULF1 inhibits tumor growth and potentiates the effects of histone deacetylase inhibitors in hepatocellular carcinoma. Lai, J.P., Yu, C., Moser, C.D., Aderca, I., Han, T., Garvey, T.D., Murphy, L.M., Garrity-Park, M.M., Shridhar, V., Adjei, A.A., Roberts, L.R. Gastroenterology (2006) [Pubmed]
  38. Different HATS of the ING1 gene family. Feng, X., Hara, Y., Riabowol, K. Trends Cell Biol. (2002) [Pubmed]
  39. Post-transcriptional regulation of Smad7 in the gut of patients with inflammatory bowel disease. Monteleone, G., Del Vecchio Blanco, G., Monteleone, I., Fina, D., Caruso, R., Gioia, V., Ballerini, S., Federici, G., Bernardini, S., Pallone, F., MacDonald, T.T. Gastroenterology (2005) [Pubmed]
  40. Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity. Ray, S., Sherman, C.T., Lu, M., Brasier, A.R. Mol. Endocrinol. (2002) [Pubmed]
  41. Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes. Helmlinger, D., Hardy, S., Sasorith, S., Klein, F., Robert, F., Weber, C., Miguet, L., Potier, N., Van-Dorsselaer, A., Wurtz, J.M., Mandel, J.L., Tora, L., Devys, D. Hum. Mol. Genet. (2004) [Pubmed]
  42. Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF. Moore, S.D., Herrick, S.R., Ince, T.A., Kleinman, M.S., Cin, P.D., Morton, C.C., Quade, B.J. Cancer Res. (2004) [Pubmed]
  43. Site specificity of pea histone acetyltransferase B in vitro. Mingarro, I., Sendra, R., Salvador, M.L., Franco, L. J. Biol. Chem. (1993) [Pubmed]
  44. The transforming acidic coiled coil proteins interact with nuclear histone acetyltransferases. Gangisetty, O., Lauffart, B., Sondarva, G.V., Chelsea, D.M., Still, I.H. Oncogene (2004) [Pubmed]
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