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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phylogenetic evidence for recombination in dengue virus.

A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4. Within DEN-1, two viruses sampled from South America in the last 10 years were identified as recombinants. To map the breakpoints and test their statistical support, we developed a novel maximum likelihood method. In both recombinants, the breakpoints were found to be in similar positions, within the fusion peptide of the envelope protein, demonstrating that a single recombination event occurred prior to the divergence of these two strains. This is the first report of recombination in natural populations of dengue virus.[1]


  1. Phylogenetic evidence for recombination in dengue virus. Holmes, E.C., Worobey, M., Rambaut, A. Mol. Biol. Evol. (1999) [Pubmed]
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