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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall.

Surface proteins of Gram-positive bacteria are linked to the bacterial cell wall by a mechanism that involves cleavage of a conserved Leu-Pro-X-Thr-Gly (LPXTG) motif and that occurs during assembly of the peptidoglycan cell wall. A Staphylococcus aureus mutant defective in the anchoring of surface proteins was isolated and shown to carry a mutation in the srtA gene. Overexpression of srtA increased the rate of surface protein anchoring, and homologs of srtA were found in other pathogenic Gram-positive bacteria. The protein specified by srtA, sortase, may be a useful target for the development of new antimicrobial drugs.[1]

References

  1. Staphylococcus aureus sortase, an enzyme that anchors surface proteins to the cell wall. Mazmanian, S.K., Liu, G., Ton-That, H., Schneewind, O. Science (1999) [Pubmed]
 
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