- The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1,N11-bis(ethyl)norspermine. Gabrielson, E.W., Pegg, A.E., Casero, R.A. Clin. Cancer Res. (1999)