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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Injectable bone substitute using a hydrophilic polymer.

We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential to the production of a ready-to-use injectable biomaterial. These flow properties are necessary to obtain CaP bioactivity in a dental canal or bone defect during percutaneous surgery. Macromolecules provide spaces between CaP ceramic granules and facilitate the role of the biological agents of bone substitution.[1]


  1. Injectable bone substitute using a hydrophilic polymer. Weiss, P., Gauthier, O., Bouler, J.M., Grimandi, G., Daculsi, G. Bone (1999) [Pubmed]
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