Disease relevance of tricalcium diphosphate

• In the Gunn rat model of unconjugated hyperbilirubinemia, dietary supplementation with the lipase inhibitor orlistat (Orl) or with calcium phosphate (CaP) decreases plasma unconjugated bilirubin (UCB) levels [1].
• Octacalcium phosphate (OCP) was found in all samples except that from a patient with synovial chondromatosis which contained tricalcium phosphate (TCP) [2].
• Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia [3].
• In contrast, using the CaPO4 coprecipitation method, 18% of PGCs transfected with plasmid pSV-LT expressed simian virus 40 large tumor antigen (SV 40 T-Ag) transiently [4].
• Calcium phosphate precipitates were used to cotransfect Shope fibroma virus-infected cells with different DNA substrates and the recombinant products assayed by genetic and biochemical methods [5].

Psychiatry related information on tricalcium diphosphate

• Observations of behaviors of Social Interaction, Spatial Localization, and Posture categories were made under music (folk or rock and roll) and no music conditions [6].

High impact information on tricalcium diphosphate

• Calcium phosphate granules in muscle cells of Nephtys (Annelida, Polychaeta)--a novel skeleton [7]?
• Calcium phosphate (CaPi) precipitates have been used to deliver plasmid DNA to cultured cell lines [8].
• Our results suggest that heritable changes in malignant behavior of transfected tumor cells can be observed at high frequency subsequent to the process of Ca3(PO4)2-mediated DNA transfection, and these changes may be brought about in part by inherited disturbances in expression of recipient cell genes [9].
• During the course of studies designed to assess the effect of human Ha-ras gene expression on the malignant behavior of transfected mouse tumor cells we noted that the process of Ca3(PO4)2-mediated DNA transfection was itself associated with profound alterations in tumorigenic or metastatic behavior [9].
• Calcium phosphate-precipitated DNA was injected directly into mouse organs in combination with hyaluronidase and collagenase [10].

Chemical compound and disease context of tricalcium diphosphate

• As well, increasing CaP content was associated with falling urine citrate and rising urine pH, suggesting renal tubular acidosis [11].
• OBJECTIVE: To determine if hydroxyapatite (HAP), octacalcuim phosphate (OCP), or tricalcium phosphate (TCP) can be found in the calcium deposits in calcific periarthritis [12].
• CLON, infused in the medial basal hypothalamus (MBH) of EB-primed females, increased the percentage of females showing lordosis 15-45 min after infusion (p < 0.05) and also increased the number of seconds females held the lordosis posture 15 min to approximately 2.0 h after infusion (by as much as 65% at 15 min p < 0.001) [13].
• The biologic principles for successful distraction osteogenesis by this innovative technique are illustrated in a 41-year-old man with chronic cavitary (150 cc) (four years) osteomyelitis refractory to multiple debridements, Papineau grafting, gentamicin beads, and tricalcium phosphate [14].
• The purpose of this study was to compare the effectiveness of a tricalcium phosphate, plaster of paris, and doxycycline composite graft to surgical debridement alone in the treatment of Class II and Class III furcation defects [15].

Biological context of tricalcium diphosphate

• Calcium phosphate-mediated transfection alters metallothionein gene expression in response to Cd2+ and Zn2+ [16].
• Calcium phosphate-mediated transfer of minigene DNA into DHFR gene-deleted Chinese hamster ovary cells converted these cells to a DHFR+ phenotype at a frequency of 0.12% [17].
• Calcium phosphate-mediated DNA transfection and retroviral infection are two alternative gene transfer techniques designed to introduce specific DNA fragments into the chromosomes of recipient cells [18].
• Consistent bone formation by human MSFs was achieved only within vehicles containing hydroxyapatite/tricalcium phosphate ceramics (HA/TCP) in the form of blocks, powder, and HA/TCP powder-type I bovine fibrillar collagen strips, and bone was maintained for at least 19 weeks [19].
• Calcium (Ca)-fortified soymilk has gained popularity in the United States. Tricalcium phosphate (TCP)-fortified soymilk was shown to have a lower Ca bioavailability than cow's milk in men [20].

Anatomical context of tricalcium diphosphate

• The constitutive transcription of a mouse alpha-fetoprotein (AFP) minigene was examined during the transient expression of AFP-simian virus 40-pBR322 recombinant DNAs introduced into HeLa cells by Ca3(PO4)2 precipitation [21].
• Crystal populations in human synovial fluid. Identification of apatite, octacalcium phosphate, and tricalcium phosphate [2].
• This construct was introduced into various mammalian cell lines and primary cultures via Ca3(PO4)2 precipitation [22].
• Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo [23].
• Calcium phosphate transfection leads to the accumulation of recombinant FN in cytoplasmic vesicles of both matrix-forming and nonforming cells [24].

Associations of tricalcium diphosphate with other chemical compounds

• The supernatants were collected immediately prior to transfection, after 5-h incubation with lipofectin or Ca3(PO4)2, and 24 and 48 h after transfection [25].
• The following transfection methods were compared: lipofection with lipofectACE and lipofectAMINE (GIBCO), Ca3(PO4)2 co-precipitation, and polybrene-dimethylsulfoxide (DMSO) [25].
• The following methods were compared: electroporation, lipofection, Ca3(PO4)2 co-precipitation, DEAE-dextran, and polybrene-mediated transfection [26].
• Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration [27].
• Spinal recurrent inhibition via Renshaw cells and proprioceptive feedback via skeletal muscle and muscle spindle afferents have been hypothesized to constitute a compound feedback system [Windhorst (1989) Afferent Control of Posture and Locomotion; Windhorst (1993) Robots and Biological Systems--Towards a New Bionics] [28].

Gene context of tricalcium diphosphate

• When compared with wild-type controls, IL-6 -/- mice showed a higher degree of aggressive behaviour as indicated by a higher frequency of Offensive Upright Posture, an effect more pronounced on the fifth encounter [29].
• Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects [30].
• The interaction of NPG and NPG-GMA with Ca3(PO4)2 and 45Ca3(PO4)2 was studied in aqueous, alcoholic and aqueous-alcoholic solutions [31].
• The effect of autogenous marrow and calcitonin on reactions to a tricalcium phosphate ceramic was studied by subcutaneous implantation in rats [32].
• Ether precipitation of globulins from the supernatant fraction of prothrombin complex concentrate, followed by adsorption on tricalcium phosphate and elution gives a beta2 fraction termed Bridge anticoagulant neutralizing agent (BANA) [33].

Analytical, diagnostic and therapeutic context of tricalcium diphosphate

• 2. Gel-filtration, (NH4)2SO4 fractionation, Ca3(PO4)2 fractionation and ion-exchange chromatography were used [34].
• We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers [35].
• Calcium phosphate materials have been increasingly employed in orthopedic and dental applications in recent years and are now being developed for use in noninvasive surgery or as carriers for drug delivery systems [36].
• Calcium phosphate hydraulic cements are promising synthetic bone grafting materials [37].
• CONCLUSIONS: Use of slow-release antibiotic loaded onto a TCP block, along with debridement, may control infection in vascular grafts in situ, averting the necessity to remove the graft [38].

References