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Chemical Compound Review

Monetite     tricalcium diphosphate

Synonyms: Bonarka, Synthos, alpha-TCP, Posture (TN), AC1LANN3, ...
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Disease relevance of tricalcium diphosphate


Psychiatry related information on tricalcium diphosphate


High impact information on tricalcium diphosphate

  • Calcium phosphate granules in muscle cells of Nephtys (Annelida, Polychaeta)--a novel skeleton [7]?
  • Calcium phosphate (CaPi) precipitates have been used to deliver plasmid DNA to cultured cell lines [8].
  • Our results suggest that heritable changes in malignant behavior of transfected tumor cells can be observed at high frequency subsequent to the process of Ca3(PO4)2-mediated DNA transfection, and these changes may be brought about in part by inherited disturbances in expression of recipient cell genes [9].
  • During the course of studies designed to assess the effect of human Ha-ras gene expression on the malignant behavior of transfected mouse tumor cells we noted that the process of Ca3(PO4)2-mediated DNA transfection was itself associated with profound alterations in tumorigenic or metastatic behavior [9].
  • Calcium phosphate-precipitated DNA was injected directly into mouse organs in combination with hyaluronidase and collagenase [10].

Chemical compound and disease context of tricalcium diphosphate


Biological context of tricalcium diphosphate


Anatomical context of tricalcium diphosphate


Associations of tricalcium diphosphate with other chemical compounds


Gene context of tricalcium diphosphate

  • When compared with wild-type controls, IL-6 -/- mice showed a higher degree of aggressive behaviour as indicated by a higher frequency of Offensive Upright Posture, an effect more pronounced on the fifth encounter [29].
  • Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects [30].
  • The interaction of NPG and NPG-GMA with Ca3(PO4)2 and 45Ca3(PO4)2 was studied in aqueous, alcoholic and aqueous-alcoholic solutions [31].
  • The effect of autogenous marrow and calcitonin on reactions to a tricalcium phosphate ceramic was studied by subcutaneous implantation in rats [32].
  • Ether precipitation of globulins from the supernatant fraction of prothrombin complex concentrate, followed by adsorption on tricalcium phosphate and elution gives a beta2 fraction termed Bridge anticoagulant neutralizing agent (BANA) [33].

Analytical, diagnostic and therapeutic context of tricalcium diphosphate


  1. Effective oral treatment of unconjugated hyperbilirubinemia in Gunn rats. Hafkamp, A.M., Havinga, R., Sinaasappel, M., Verkade, H.J. Hepatology (2005) [Pubmed]
  2. Crystal populations in human synovial fluid. Identification of apatite, octacalcium phosphate, and tricalcium phosphate. McCarty, D.J., Lehr, J.R., Halverson, P.B. Arthritis Rheum. (1983) [Pubmed]
  3. Calcium phosphate metabolism and bone disease in patients with homozygous thalassemia. de Vernejoul, M.C., Girot, R., Gueris, J., Cancela, L., Bang, S., Bielakoff, J., Mautalen, C., Goldberg, D., Miravet, L. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  4. Gene transfection of mouse primordial germ cells in vitro and analysis of their survival and growth control. Watanabe, M., Shirayoshi, Y., Koshimizu, U., Hashimoto, S., Yonehara, S., Eguchi, Y., Tsujimoto, Y., Nakatsuji, N. Exp. Cell Res. (1997) [Pubmed]
  5. Heteroduplex DNA formation is associated with replication and recombination in poxvirus-infected cells. Fisher, C., Parks, R.J., Lauzon, M.L., Evans, D.H. Genetics (1991) [Pubmed]
  6. Influence of background music on preschoolers' behavior: a naturalistic approach. Godeli, M.R., Santana, P.R., Souza, V.H., Marquetti, G.P. Perceptual and motor skills. (1996) [Pubmed]
  7. Calcium phosphate granules in muscle cells of Nephtys (Annelida, Polychaeta)--a novel skeleton? Gibbs, P.E., Bryan, G.W. Nature (1984) [Pubmed]
  8. Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo. Fasbender, A., Lee, J.H., Walters, R.W., Moninger, T.O., Zabner, J., Welsh, M.J. J. Clin. Invest. (1998) [Pubmed]
  9. Alteration of the tumorigenic and metastatic properties of neoplastic cells is associated with the process of calcium phosphate-mediated DNA transfection. Kerbel, R.S., Waghorne, C., Man, M.S., Elliott, B., Breitman, M.L. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. Direct transfection of viral and plasmid DNA into the liver or spleen of mice. Dubensky, T.W., Campbell, B.A., Villarreal, L.P. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  11. Correspondence between stone composition and urine supersaturation in nephrolithiasis. Parks, J.H., Coward, M., Coe, F.L. Kidney Int. (1997) [Pubmed]
  12. Analysis of calcium deposits in calcific periarthritis. Hamada, J., Ono, W., Tamai, K., Saotome, K., Hoshino, T. J. Rheumatol. (2001) [Pubmed]
  13. Effects of clonidine and phentolamine infused into the medial preoptic area and medial basal hypothalamus of the guinea pig. Malik, K.F., Morrell, J.I., Feder, H.H. Neuroendocrinology (1993) [Pubmed]
  14. Cavitary osteomyelitis treated by fragmentary cortical bone transportation. Aronson, J. Clin. Orthop. Relat. Res. (1992) [Pubmed]
  15. Doxycycline-tricalcium phosphate composite graft facilitates osseous healing in advanced periodontal furcation defects. Pepelassi, E.M., Bissada, N.F., Greenwell, H., Farah, C.F. J. Periodontol. (1991) [Pubmed]
  16. Calcium phosphate-mediated transfection alters metallothionein gene expression in response to Cd2+ and Zn2+. Foster, R., Olsson, P.E., Gedamu, L. Mol. Cell. Biol. (1989) [Pubmed]
  17. 5' Nucleotide sequences influence serum-modulated expression of a human dihydrofolate reductase minigene. Goldsmith, M.E., Beckman, C.A., Cowan, K.H. Mol. Cell. Biol. (1986) [Pubmed]
  18. Expression of genes introduced into cells by retroviral infection is more efficient than that of genes introduced into cells by DNA transfection. Hwang, L.H., Gilboa, E. J. Virol. (1984) [Pubmed]
  19. Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Krebsbach, P.H., Kuznetsov, S.A., Satomura, K., Emmons, R.V., Rowe, D.W., Robey, P.G. Transplantation (1997) [Pubmed]
  20. Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow's milk in young women. Zhao, Y., Martin, B.R., Weaver, C.M. J. Nutr. (2005) [Pubmed]
  21. Transient expression of a mouse alpha-fetoprotein minigene: deletion analyses of promoter function. Scott, R.W., Tilghman, S.M. Mol. Cell. Biol. (1983) [Pubmed]
  22. Epithelial-specific keratin gene expression: identification of a 300 base-pair controlling segment. Jiang, C.K., Epstein, H.S., Tomic, M., Freedberg, I.M., Blumenberg, M. Nucleic Acids Res. (1990) [Pubmed]
  23. Calcium phosphate precipitates augment adenovirus-mediated gene transfer to blood vessels in vitro and in vivo. Toyoda, K., Andresen, J.J., Zabner, J., Faraci, F.M., Heistad, D.D. Gene Ther. (2000) [Pubmed]
  24. Generation of full-length cDNA recombinant vectors for the transient expression of human fibronectin in mammalian cell lines. Dufour, S., Gutman, A., Bois, F., Lamb, N., Thiery, J.P., Kornblihtt, A.R. Exp. Cell Res. (1991) [Pubmed]
  25. Interleukin-1 alpha is released during transfection of keratinocytes. Komine, M., Freedberg, I.M., Blumenberg, M. J. Invest. Dermatol. (1994) [Pubmed]
  26. Comparison of methods for transfection of human epidermal keratinocytes. Jiang, C.K., Connolly, D., Blumenberg, M. J. Invest. Dermatol. (1991) [Pubmed]
  27. Calcium phosphate drug delivery system: influence of local zoledronate release on bone implant osteointegration. Peter, B., Pioletti, D.P., Laïb, S., Bujoli, B., Pilet, P., Janvier, P., Guicheux, J., Zambelli, P.Y., Bouler, J.M., Gauthier, O. Bone (2005) [Pubmed]
  28. Signal transmission from motor axons to group Ia muscle spindle afferents: frequency responses and second-order non-linearities. Windhorst, U., Kokkoroyiannis, T., Laouris, Y., Meyer-Lohmann, J. Neuroscience (1994) [Pubmed]
  29. Behavioural characterization of interleukin-6 overexpressing or deficient mice during agonistic encounters. Alleva, E., Cirulli, F., Bianchi, M., Bondiolotti, G.P., Chiarotti, F., De Acetis, L., Panerai, A.E. Eur. J. Neurosci. (1998) [Pubmed]
  30. Evaluation of human recombinant bone morphogenetic protein-2-loaded tricalcium phosphate implants in rabbits' bone defects. Laffargue, P., Hildebrand, H.F., Rtaimate, M., Frayssinet, P., Amoureux, J.P., Marchandise, X. Bone (1999) [Pubmed]
  31. Character of the hard tooth tissue-polymer bond. I. Study of the interaction of calcium phosphate with N-phenylglycine and with N-phenylglycine-glycidyl methacrylate adduct. Alexieva, C. J. Dent. Res. (1979) [Pubmed]
  32. Effect of autogenous marrow and calcitonin on reactions to a ceramic. McDavid, P.T., Boone, M.E., Kafrawy, A.H., Mitchell, D.F. J. Dent. Res. (1979) [Pubmed]
  33. Ultrasonic purification of Bridge anticoagulant neutralizing agent (BANA) and a study on its effect on factor VIII inhibitor. Nour-Eldin, F. Transfusion (1979) [Pubmed]
  34. Partial purification of two lithocholic acid-binding proteins from rat liver 100 000g supernatants. Strange, R.C., Cramb, R., Hayes, J.D., Percy-Robb, I.W. Biochem. J. (1977) [Pubmed]
  35. Injectable bone substitute using a hydrophilic polymer. Weiss, P., Gauthier, O., Bouler, J.M., Grimandi, G., Daculsi, G. Bone (1999) [Pubmed]
  36. Biphasic calcium phosphate/hydrosoluble polymer composites: a new concept for bone and dental substitution biomaterials. Daculsi, G., Weiss, P., Bouler, J.M., Gauthier, O., Millot, F., Aguado, E. Bone (1999) [Pubmed]
  37. Raman microspectrometry studies of brushite cement: in vivo evolution in a sheep model. Penel, G., Leroy, N., Van Landuyt, P., Flautre, B., Hardouin, P., Lemaître, J., Leroy, G. Bone (1999) [Pubmed]
  38. Graft-preserving treatment for vascular graft infected with Staphylococcus aureus with antibiotic-releasing porous apatite ceramic in the rabbit. Murase, K., Hirose, H., Mori, Y., Takagi, H., Iwata, H., Sago, T., Kawamura, Y. J. Vasc. Surg. (2003) [Pubmed]
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