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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7.

We had previously described six distinct alleles of the glycoprotein B (gB) gene of human herpesvirus 7 (HHV-7). The genetic changes corresponding to these alleles did not affect gB gene transcription or translation in in vitro assays. The study of distinct HHV-7-positive human samples showed preferential associations of some gB alleles with some alleles of two other genes, distantly located on the HHV-7 genome, coding for the phosphoprotein p100 ( p100) and the major capsid protein ( MCP). Two allele combinations, corresponding to 44 and 31% of the samples studied, respectively, were interpreted as the genetic signatures of two major prototype HHV-7 variants.[1]

References

  1. Preferential associations of alleles of three distinct genes argue for the existence of two prototype variants of human herpesvirus 7. Franti, M., Aubin, J.T., Gautheret-Dejean, A., Malet, I., Cahour, A., Huraux, J.M., Agut, H. J. Virol. (1999) [Pubmed]
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