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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site.

To get an insight into the bioactive conformation of glutamic acid and its topological environment at the mGluR4 binding site, a pharmacophore model was constructed using molecular modeling. Agonists of known activities were used to run the Apex-3D program or to validate the resulting model. An extended glutamate conformer, two selective hydrophilic sites and bulk tolerance regions are disclosed. Selective features of mGluR1, mGluR2 and mGluR4 are discussed.[1]

References

  1. Extended glutamate activates metabotropic receptor types 1, 2 and 4: selective features at mGluR4 binding site. Bessis, A.S., Jullian, N., Coudert, E., Pin, J.P., Acher, F. Neuropharmacology (1999) [Pubmed]
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