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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Differences in lung bioavailability between different propellants for fluticasone propionate.

The lung bioavailability (as adrenal suppression) of fluticasone propionate was about twofold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a microg equivalent may therefore be inadvisable.[1]

References

  1. Differences in lung bioavailability between different propellants for fluticasone propionate. Wilson, A.M., Sims, E.J., Orr, L.C., Lipworth, B.J. Lancet (1999) [Pubmed]
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