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Chemical Compound Review

Fluticaps     (6S,9S,10S,11S,13S,14S,16R,17R )-6,9...

Synonyms: Fluticaps (TN), AC1NSJZT, AC-456, CHEMBL1201396, BIDD:GT0819, ...
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Disease relevance of fluticasone


Psychiatry related information on fluticasone

  • The frequencies of hemoglobin desaturation and respiratory movement/arousals also decreased more in the fluticasone group [6].

High impact information on fluticasone


Chemical compound and disease context of fluticasone


Biological context of fluticasone


Anatomical context of fluticasone


Associations of fluticasone with other chemical compounds


Gene context of fluticasone

  • Numbers of IL-4+ cells in the nasal submucosa were significantly suppressed by treatment with fluticasone (p = 0.0003 for monoclonal antibody [mAb] 3H4, p = 0.041 for mAb 4D9) [30].
  • Allergen-specific T cell lines induced in the presence of salmeterol and fluticasone proprionate inhibited IL-5 and IL-13 production by allergen-specific Th2 cell lines in an IL-10-dependent manner [31].
  • After 1 h pretreatment, combined treatment significantly inhibited rhinovirus 16, 1B, and IL-1beta-induced CCL5 and CXCL8 protein and mRNA production in BEAS-2B cells compared with fluticasone alone [32].
  • Both bFGF-induced fibroblast proliferation and TNF-alpha-induced ICAM-1 expression were significantly reduced by fluticasone, starting at the dose of 1 and 10 nM, respectively (p < 0.05) [33].
  • Intranasal fluticasone was effective in decreasing nasal airflow resistance and intra-epithelial eosinophils but had no effect on mucin or epidermal growth factor receptor expression or on neutrophil recruitment [34].

Analytical, diagnostic and therapeutic context of fluticasone

  • Inhaled fluticasone propionate delivered by means of two different multidose powder inhalers is effective and safe in a large pediatric population with persistent asthma [35].
  • METHODS: We performed a double-blind, randomized, placebo-controlled crossover study with inhaled fluticasone, 500 microg twice daily, and placebo for 14 days in 88 patients with cough for more than 1 year, with normal chest radiography and spirometry results [36].
  • Subjects with a baseline FEV1 of less than 1 L treated with fluticasone showed a significant increase in pulmonary function (p = 0.001) and a significant decrease in hospitalization rate (p = 0.05) [37].
  • By comparison, 2 randomized controlled clinical trials with fluticasone, 50 to 100 microg twice daily via dry powder inhaler, could not detect differences in height velocity in prepubertal children treated with cromolyn sodium or placebo [19].
  • We measured serum GBA (bioassay) and cortisol (RIA) levels in 34 asthmatic children (age range, 5.7-14.2 yr) at baseline and after treatment with either inhaled budesonide (800 microg/d, n = 14), fluticasone propionate (500 microg/d, n = 14), or cromones (control group, n = 6) [38].


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  2. Iatrogenic Cushing's syndrome in an HIV-infected patient treated with ritonavir and inhaled fluticasone. Gillett, M.J., Cameron, P.U., Nguyen, H.V., Hurley, D.M., Mallal, S.A. AIDS (2005) [Pubmed]
  3. Oral fluticasone propionate in active distal ulcerative colitis. Angus, P., Snook, J.A., Reid, M., Jewell, D.P. Gut (1992) [Pubmed]
  4. Fluticasone propionate in Crohn's disease. de Kaski, M.C., Peters, A.M., Lavender, J.P., Hodgson, H.J. Gut (1991) [Pubmed]
  5. A comparison of triamcinolone acetonide nasal aerosol spray and fluticasone propionate aqueous solution spray in the treatment of spring allergic rhinitis. Small, P., Houle, P.A., Day, J.H., Briscoe, M., Gold, M., Brodarec, I., Ham Pong, A., Mandl, M., Spénard, J., Phillips, R., Furlan, M. J. Allergy Clin. Immunol. (1997) [Pubmed]
  6. Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea. Brouillette, R.T., Manoukian, J.J., Ducharme, F.M., Oudjhane, K., Earle, L.G., Ladan, S., Morielli, A. J. Pediatr. (2001) [Pubmed]
  7. Comparison of pharmacokinetics and systemic effects of inhaled fluticasone propionate in patients with asthma and healthy volunteers: a randomised crossover study. Brutsche, M.H., Brutsche, I.C., Munawar, M., Langley, S.J., Masterson, C.M., Daley-Yates, P.T., Brown, R., Custovic, A., Woodcock, A. Lancet (2000) [Pubmed]
  8. Differences in lung bioavailability between different propellants for fluticasone propionate. Wilson, A.M., Sims, E.J., Orr, L.C., Lipworth, B.J. Lancet (1999) [Pubmed]
  9. Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group. Paggiaro, P.L., Dahle, R., Bakran, I., Frith, L., Hollingworth, K., Efthimiou, J. Lancet (1998) [Pubmed]
  10. Identification of the integral membrane protein RM3/1 on human monocytes as a glucocorticoid-inducible member of the scavenger receptor cysteine-rich family (CD163). Högger, P., Dreier, J., Droste, A., Buck, F., Sorg, C. J. Immunol. (1998) [Pubmed]
  11. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Mahler, D.A., Wire, P., Horstman, D., Chang, C.N., Yates, J., Fischer, T., Shah, T. Am. J. Respir. Crit. Care Med. (2002) [Pubmed]
  12. Salmeterol resolves airway obstruction but does not possess anti-eosinophil efficacy in newly diagnosed asthma: a randomized, double-blind, parallel group biopsy study comparing the effects of salmeterol, fluticasone propionate, and disodium cromoglycate. Lindqvist, A., Karjalainen, E.M., Laitinen, L.A., Kava, T., Altraja, A., Pulkkinen, M., Halme, M., Laitinen, A. J. Allergy Clin. Immunol. (2003) [Pubmed]
  13. Steroid naive eosinophilic asthma: anti-inflammatory effects of fluticasone and montelukast. Jayaram, L., Pizzichini, E., Lemière, C., Man, S.F., Cartier, A., Hargreave, F.E., Pizzichini, M.M. Thorax (2005) [Pubmed]
  14. Intranasal fluticasone propionate. A reappraisal of its pharmacology and clinical efficacy in the treatment of rhinitis. Wiseman, L.R., Benfield, P. Drugs (1997) [Pubmed]
  15. Influence of intranasal steroids during the grass pollen season on bronchial responsiveness in children and young adults with asthma and hay fever. Thio, B.J., Slingerland, G.L., Fredriks, A.M., Nagelkerke, A.F., Scheeren, R.A., Neijens, H.J., Roord, J.J., Dankert-Roelse, J.E. Thorax (2000) [Pubmed]
  16. Flovent (fluticasone propionate inhalation aerosol). Levy, D.S. J. Allergy Clin. Immunol. (1997) [Pubmed]
  17. Fluticasone improves pulmonary function in children under 2 years old with risk factors for asthma. Teper, A.M., Kofman, C.D., Szulman, G.A., Vidaurreta, S.M., Maffey, A.F. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  18. Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. Pace, E., Gagliardo, R., Melis, M., La Grutta, S., Ferraro, M., Siena, L., Bonsignore, G., Gjomarkaj, M., Bousquet, J., Vignola, A.M. J. Allergy Clin. Immunol. (2004) [Pubmed]
  19. Establishing a therapeutic index for the inhaled corticosteroids: part II. Comparisons of systemic activity and safety among different inhaled corticosteroids. Sorkness, C.A. J. Allergy Clin. Immunol. (1998) [Pubmed]
  20. Fluticasone propionate plasma concentration and systemic effect: effect of delivery device and duration of administration. Whelan, G.J., Blumer, J.L., Martin, R.J., Szefler, S.J. J. Allergy Clin. Immunol. (2005) [Pubmed]
  21. Superiority of an intranasal corticosteroid compared with an oral antihistamine in the as-needed treatment of seasonal allergic rhinitis. Kaszuba, S.M., Baroody, F.M., deTineo, M., Haney, L., Blair, C., Naclerio, R.M. Arch. Intern. Med. (2001) [Pubmed]
  22. Inhaled fluticasone reduces sputum inflammatory indices in severe bronchiectasis. Tsang, K.W., Ho, P.L., Lam, W.K., Ip, M.S., Chan, K.N., Ho, C.S., Ooi, C.C., Yuen, K.Y. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  23. Effects of topical corticosteroids on inflammatory mediator-induced eicosanoid release by human airway epithelial cells. Aksoy, M.O., Li, X., Borenstein, M., Yi, Y., Kelsen, S.G. J. Allergy Clin. Immunol. (1999) [Pubmed]
  24. Nasal eosinophilia and IL-5 mRNA expression in seasonal allergic rhinitis induced by natural allergen exposure: effect of topical corticosteroids. Masuyama, K., Till, S.J., Jacobson, M.R., Kamil, A., Cameron, L., Juliusson, S., Lowhagen, O., Kay, A.B., Hamid, Q.A., Durham, S.R. J. Allergy Clin. Immunol. (1998) [Pubmed]
  25. Regulation of glucocorticoid receptor mRNA in nasal mucosa by local administration of fluticasone and budesonide. Knutsson, P.U., Brönnegård, M., Marcus, C., Stierna, P. J. Allergy Clin. Immunol. (1996) [Pubmed]
  26. Short-term and long-term asthma control in patients with mild persistent asthma receiving montelukast or fluticasone: a randomized controlled trial. Zeiger, R.S., Bird, S.R., Kaplan, M.S., Schatz, M., Pearlman, D.S., Orav, E.J., Hustad, C.M., Edelman, J.M. Am. J. Med. (2005) [Pubmed]
  27. Intranasal fluticasone propionate is more effective than terfenadine tablets for seasonal allergic rhinitis. van Bavel, J., Findlay, S.R., Hampel, F.C., Martin, B.G., Ratner, P., Field, E. Arch. Intern. Med. (1994) [Pubmed]
  28. Adding salmeterol to an inhaled corticosteroid reduces allergen-induced serum IL-5 and peripheral blood eosinophils. Koopmans, J.G., Lutter, R., Jansen, H.M., van der Zee, J.S. J. Allergy Clin. Immunol. (2005) [Pubmed]
  29. Once daily fluticasone propionate is as effective for perennial allergic rhinitis as twice daily beclomethasone diproprionate. van As, A., Bronsky, E.A., Dockhorn, R.J., Grossman, J., Lumry, W., Meltzer, E.O., Seltzer, J.M., Rogenes, P.R. J. Allergy Clin. Immunol. (1993) [Pubmed]
  30. Cytokine immunoreactivity in seasonal rhinitis: regulation by a topical corticosteroid. Bradding, P., Feather, I.H., Wilson, S., Holgate, S.T., Howarth, P.H. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  31. Interleukin-10-secreting "regulatory" T cells induced by glucocorticoids and beta2-agonists. Peek, E.J., Richards, D.F., Faith, A., Lavender, P., Lee, T.H., Corrigan, C.J., Hawrylowicz, C.M. Am. J. Respir. Cell Mol. Biol. (2005) [Pubmed]
  32. Combination therapy: synergistic suppression of virus-induced chemokines in airway epithelial cells. Edwards, M.R., Johnson, M.W., Johnston, S.L. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  33. Fluticasone propionate downregulates nasal fibroblast functions involved in airway inflammation and remodeling. Silvestri, M., Sabatini, F., Scarso, L., Cordone, A., Dasic, G., Rossi, G.A. Int. Arch. Allergy Immunol. (2002) [Pubmed]
  34. Intranasal steroids decrease eosinophils but not mucin expression in nasal polyps. Burgel, P.R., Cardell, L.O., Ueki, I.F., Nadel, J.A. Eur. Respir. J. (2004) [Pubmed]
  35. Inhaled fluticasone propionate delivered by means of two different multidose powder inhalers is effective and safe in a large pediatric population with persistent asthma. Peden, D.B., Berger, W.E., Noonan, M.J., Thomas, M.R., Hendricks, V.L., Hamedani, A.G., Mahajan, P., House, K.W. J. Allergy Clin. Immunol. (1998) [Pubmed]
  36. Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough. Chaudhuri, R., McMahon, A.D., Thomson, L.J., MacLeod, K.J., McSharry, C.P., Livingston, E., McKay, A., Thomson, N.C. J. Allergy Clin. Immunol. (2004) [Pubmed]
  37. Comparison of inhaled fluticasone with intravenous hydrocortisone in the treatment of adult acute asthma. Rodrigo, G.J. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  38. Transactivation assay for determination of glucocorticoid bioactivity in human serum. Raivio, T., Palvimo, J.J., Kannisto, S., Voutilainen, R., Jänne, O.A. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
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