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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Alternative splicing of the Drosophila PTEN gene.

Mutations in the human PTEN gene have been identified in a number of different tumour types, and in the hamartomatous polyposis syndromes Cowden disease and Bannayan-Zonana syndrome. The PTEN gene encodes a phosphatase that antagonises phosphoinositide 3-kinase ( PI3K) signalling by removing the 3' phosphate from phosphatidylinositol 3, 4,5-trisphosphate (PtdIns (3,4,5)P(3)). Here we show that the PTEN gene is conserved in the invertebrate Drosophila melanogaster and demonstrate that the gene undergoes alternative splicing.[1]


  1. Alternative splicing of the Drosophila PTEN gene. Smith, A., Smith, A., Alrubaie, S., Coehlo, C., Leevers, S.J., Ashworth, A. Biochim. Biophys. Acta (1999) [Pubmed]
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