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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Studies on the effect of growth hormone in vivo and in vitro on lipogenic enzymes and transaminases in a teleost Anabas testudineus (BLOCH).

The specific activities of three lipogenic enzymes, malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PDH) and isocitrate dehydrogenase (ICDH), in liver and heart and two transaminases (AST & ALT) in liver and muscle, were studied in response to the in vivo and in vitro administration of growth hormone ( GH) in a teleost Anabas testudineus. Ovine growth hormone (oGH) in vivo significantly reduced the activities of lipogenic enzymes, except for heart G6PDH, which showed an increase at the highest dose of hormone. Transaminase activity either increased or decreased depending on the dose of GH. The lowest dose of hormone employed (0.1 microg/gm b/w) exhibited a stimulatory effect and the highest dose (0.5 microg/gm. b/w) an inhibitory effect on transaminase activity. Both ovine GH and carp GH (oGH and cGH) in vitro significantly reduced the activities of ME, G6PDH and ICDH. Activities of AST and ALT were increased by oGH and cGH in vitro. The present study reveals that irrespective of origin, GH in vitro has a direct inhibitory effect on lipogenic enzymes ME, G6PDH, ICDH and a stimulatory effect on transaminases AST and ALT in A. testudineus, thus favoring gluconeogenesis.[1]


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