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G6PD  -  glucose-6-phosphate dehydrogenase

Ovis aries

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High impact information on G6PD


Biological context of G6PD

  • Given the fact that TCA and DCA are now being found in community drinking water supplies at levels greater than 100 micrograms/liter, there is a need to further investigate their effects on biological systems, including those with a compromised ability to deal with oxidant stress (e.g., G-6-PD-deficient erythrocytes) [6].
  • No significant changes were seen in the growth rates (90 days exposure), in the plasma enzymes alkaline phosphatase, glutamic oxaloacetic transaminase, glucose 6-phosphate dehydrogenase or succinic dehydrogenase, or in the hematocrit or plasma protein concentrations after either the 90-day or 19-day exposures [7].
  • 4. The diet-induced differences in lipogenesis were reflected in significant increases in the specific activities of the fatty acid synthetase system, glucose-6-phosphate dehydrogenase and phosphogluconate dehydrogenase in concentrate fed animals [8].
  • Purification and kinetics of sheep kidney cortex glucose-6-phosphate dehydrogenase [9].
  • The present study reveals that irrespective of origin, GH in vitro has a direct inhibitory effect on lipogenic enzymes ME, G6PDH, ICDH and a stimulatory effect on transaminases AST and ALT in A. testudineus, thus favoring gluconeogenesis [10].

Anatomical context of G6PD


Associations of G6PD with chemical compounds


Other interactions of G6PD


Analytical, diagnostic and therapeutic context of G6PD

  • The effects of intramuscular injection of synthetic racemic equol (+/- 3-(4-hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol) into wethers have been examined with respect to maintenance of plasma level, teat growth rate and the activity of the respiratory enzyme glucose-6-phosphate dehydrogenase [15].


  1. Interactions of insulin and dexamethasone in the control of pyruvate kinase activity and glucose metabolism in sheep adipose tissue. Plested, C.P., Taylor, E., Brindley, D.N., Vernon, R.G. Biochem. J. (1987) [Pubmed]
  2. Glucose metabolism and its regulation in pieces of perirenal adipose tissue from foetal lambs. Robertson, J.P., Faulkner, A., Vernon, R.G. Biochem. J. (1983) [Pubmed]
  3. Porphyromonas canoris sp. nov., an asaccharolytic, black-pigmented species from the gingival sulcus of dogs. Love, D.N., Karjalainen, J., Kanervo, A., Forsblom, B., Sarkiala, E., Bailey, G.D., Wigney, D.I., Jousimies-Somer, H. Int. J. Syst. Bacteriol. (1994) [Pubmed]
  4. Sequential changes in red cell glycolytic enzymes and intermediates and possible control mechanisms in the first two months of postnatal life in lambs. Travis, S.F., Wagerle, L.C., De Alvarado, C.M., Rose, G., Delivoria-Papadopoulos, M. Pediatr. Res. (1985) [Pubmed]
  5. Characterization of porcine and ovine Oesophagostomum spp. by isoenzymatic patterns and restriction-fragment-length polymorphisms (RFLPs). Cutillas, C., Guevara-Martínez, D., Oliveros, R., Arias, P., Guevara, D.C. Acta Trop. (1999) [Pubmed]
  6. The effects of di- and trichloroacetic acid on sheep erythrocytes: an animal model with a glucose-6-phosphate dehydrogenase deficiency. Calabrese, E.J., Leonard, D.A. Regulatory toxicology and pharmacology : RTP. (1984) [Pubmed]
  7. Hexachlorobenzene II. Effects on growing lambs of prolonged low-level oral exposure to hexachlorobenzene (HCB). Mull, R.L., Winterlin, W.L., Peoples, S.A., Giri, S.N., Ocampo, L. Journal of environmental pathology and toxicology. (1978) [Pubmed]
  8. A comparison of the effects of feeding concentrate diets, based on either maize or barley, or dried grass on adipose tissue lipogenesis in sheep. Piperova, L.S., Pearce, J. Int. J. Biochem. (1982) [Pubmed]
  9. Purification and kinetics of sheep kidney cortex glucose-6-phosphate dehydrogenase. Ulusu, N.N., Tandogan, B. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2006) [Pubmed]
  10. Studies on the effect of growth hormone in vivo and in vitro on lipogenic enzymes and transaminases in a teleost Anabas testudineus (BLOCH). Leena, S., Shameena, B., Oommen, O.V. Endocr. Res. (1999) [Pubmed]
  11. Purification and characterization of glucose 6-phosphate dehydrogenase from sheep erythrocytes and inhibitory effects of some antibiotics on enzyme activity. Beydemir, S., Ciftçi, M., Küfrevioğlu, O.I. Journal of enzyme inhibition and medicinal chemistry. (2002) [Pubmed]
  12. The effects of some antibiotics on sheep lens glucose 6-phosphate dehydrogenase in vitro. Beydemir, S., Kulaçoğlu, D.N., Ciftçi, M., Küfrevioğlu, O.I. European journal of ophthalmology. (2003) [Pubmed]
  13. Tissue-specific activity of pentose cycle oxidative enzymes during feeder lamb development. Belk, K.E., Savell, J.W., Davis, S.K., Taylor, J.F., Womack, J.E., Smith, S.B. J. Anim. Sci. (1993) [Pubmed]
  14. Erythrocyte enzymes in Ovis aries. Effect of cell age. Noble, N.A., Tanaka, K.R., Nathanielsz, P.W. Comp. Biochem. Physiol., B (1982) [Pubmed]
  15. The oestrogenicity of equol in sheep. Kaziro, R., Kennedy, J.P., Cole, E.R., Southwell-Keely, P.T. J. Endocrinol. (1984) [Pubmed]
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