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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli.

Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.[1]


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