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Tse-Dinh, Y.C.

Tse-Dinh,

Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli.

Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.[1]

References

Increased sensitivity to oxidative challenges associated with topA deletion in Escherichia coli. Tse-Dinh, Y.C. J. Bacteriol. (2000) [Pubmed]

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