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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Kaufmann, G.

Kaufmann,

Anticodon nucleases.

A tRNALys-specific anticodon nuclease is kept in a latent form in a rare Escherichia coli strain, complexed with a DNA restriction enzyme. A phage T4 inhibitor of DNA restriction activates anticodon nuclease, but other T4 proteins restore tRNALys. Detection of a homologous system in Neisseria and a different anticodon nuclease in colicin E5 suggest ubiquity and diversity of such tRNA toxins. Analysis of these systems could reveal novel RNA recognition and cleavage mechanisms.[1]

References

Anticodon nucleases. Kaufmann, G. Trends Biochem. Sci. (2000) [Pubmed]

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