The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Neisseria


High impact information on Neisseria


Chemical compound and disease context of Neisseria


Biological context of Neisseria


Anatomical context of Neisseria


Gene context of Neisseria

  • Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways [24].
  • Rather, they support a model in which pilus interaction with CD46 promotes signaling cascades important for Neisseria infectivity [25].
  • Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B [26].
  • Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae [27].
  • In this study, we investigate the interaction of PorB from Neisseria meningitidis with TLR2 and describe the direct binding of a bacterial protein to TLR2 for the first time [28].

Analytical, diagnostic and therapeutic context of Neisseria


  1. Ophthalmia neonatorum caused by beta-lactamase-producing Neisseria gonorrhoeae. Doraiswamy, B., Hammerschlag, M.R., Pringle, G.F., du Bouchet, L. JAMA (1983) [Pubmed]
  2. Escherichia coli K51 and K93 capsular polysaccharides are crossreactive with the group A capsular polysaccharide of Neisseria meningitidis. Immunochemical, biological, and epidemiological studies. Guirguis, N., Schneerson, R., Bax, A., Egan, W., Robbins, J.B., Shiloach, J., Orskov, I., Orskov, F., el Kholy, A. J. Exp. Med. (1985) [Pubmed]
  3. Implications of phase variation of a gene (pgtA) encoding a pilin galactosyl transferase in gonococcal pathogenesis. Banerjee, A., Wang, R., Supernavage, S.L., Ghosh, S.K., Parker, J., Ganesh, N.F., Wang, P.G., Gulati, S., Rice, P.A. J. Exp. Med. (2002) [Pubmed]
  4. Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera. Schoolnik, G.K., Buchanan, T.M., Holmes, K.K. J. Clin. Invest. (1976) [Pubmed]
  5. The critical role of iron in host-bacterial interactions. Payne, S.M., Finkelstein, R.A. J. Clin. Invest. (1978) [Pubmed]
  6. High-level chloramphenicol resistance in Neisseria meningitidis. Galimand, M., Gerbaud, G., Guibourdenche, M., Riou, J.Y., Courvalin, P. N. Engl. J. Med. (1998) [Pubmed]
  7. Modulation of Neisseria porin (PorB) by cytosolic ATP/GTP of target cells: parallels between pathogen accommodation and mitochondrial endosymbiosis. Rudel, T., Schmid, A., Benz, R., Kolb, H.A., Lang, F., Meyer, T.F. Cell (1996) [Pubmed]
  8. The efficacy in Navajo infants of a conjugate vaccine consisting of Haemophilus influenzae type b polysaccharide and Neisseria meningitidis outer-membrane protein complex. Santosham, M., Wolff, M., Reid, R., Hohenboken, M., Bateman, M., Goepp, J., Cortese, M., Sack, D., Hill, J., Newcomer, W. N. Engl. J. Med. (1991) [Pubmed]
  9. Tetracycline-resistant Neisseria. Brewer, F., Matuszak, D.L., Libonati, J.P., Jackman, N.E., Israel, E. N. Engl. J. Med. (1986) [Pubmed]
  10. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin. Crider, S.R., Colby, S.D., Miller, L.K., Harrison, W.O., Kerbs, S.B., Berg, S.W. N. Engl. J. Med. (1984) [Pubmed]
  11. Structure of the fibre-forming protein pilin at 2.6 A resolution. Parge, H.E., Forest, K.T., Hickey, M.J., Christensen, D.A., Getzoff, E.D., Tainer, J.A. Nature (1995) [Pubmed]
  12. Net inflammatory capacity of human septic shock plasma evaluated by a monocyte-based target cell assay: identification of interleukin-10 as a major functional deactivator of human monocytes. Brandtzaeg, P., Osnes, L., Ovstebø, R., Joø, G.B., Westvik, A.B., Kierulf, P. J. Exp. Med. (1996) [Pubmed]
  13. A novel sialic acid binding site on factor H mediates serum resistance of sialylated Neisseria gonorrhoeae. Ram, S., Sharma, A.K., Simpson, S.D., Gulati, S., McQuillen, D.P., Pangburn, M.K., Rice, P.A. J. Exp. Med. (1998) [Pubmed]
  14. Mucosal infection with Neisseria gonorrhoeae. Bacterial adaptation and mucosal defenses. Cohen, M.S., Sparling, P.F. J. Clin. Invest. (1992) [Pubmed]
  15. Molecular cloning and overexpression of the human FK506-binding protein FKBP. Standaert, R.F., Galat, A., Verdine, G.L., Schreiber, S.L. Nature (1990) [Pubmed]
  16. Down-regulation of CD46 by piliated Neisseria gonorrhoeae. Gill, D.B., Koomey, M., Cannon, J.G., Atkinson, J.P. J. Exp. Med. (2003) [Pubmed]
  17. CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway. Hauck, C.R., Meyer, T.F., Lang, F., Gulbins, E. EMBO J. (1998) [Pubmed]
  18. Phase variation of lipopolysaccharide directs interconversion of invasive and immuno-resistant phenotypes of Neisseria gonorrhoeae. van Putten, J.P. EMBO J. (1993) [Pubmed]
  19. Effects of protein I of Neisseria gonorrhoeae on neutrophil activation: generation of diacylglycerol from phosphatidylcholine via a specific phospholipase C is associated with exocytosis. Haines, K.A., Reibman, J., Tang, X.Y., Blake, M., Weissmann, G. J. Cell Biol. (1991) [Pubmed]
  20. Neisseria gonorrhoeae epithelial cell interaction leads to the activation of the transcription factors nuclear factor kappaB and activator protein 1 and the induction of inflammatory cytokines. Naumann, M., Wessler, S., Bartsch, C., Wieland, B., Meyer, T.F. J. Exp. Med. (1997) [Pubmed]
  21. Phagocyte-derived lactate stimulates oxygen consumption by Neisseria gonorrhoeae. An unrecognized aspect of the oxygen metabolism of phagocytosis. Britigan, B.E., Klapper, D., Svendsen, T., Cohen, M.S. J. Clin. Invest. (1988) [Pubmed]
  22. Rapid identification of penicillinase-producing Neisseria gonorrhoeae by detection of beta-lactamase in urethral exudates. Taylor, D.N., Chen, K.C., Panikabutra, K., Wongba, C., Chitwarakern, A., Echeverria, P., Holmes, K.K. Lancet (1985) [Pubmed]
  23. Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis. Hoffmann, I., Eugène, E., Nassif, X., Couraud, P.O., Bourdoulous, S. J. Cell Biol. (2001) [Pubmed]
  24. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. Billker, O., Popp, A., Brinkmann, V., Wenig, G., Schneider, J., Caron, E., Meyer, T.F. EMBO J. (2002) [Pubmed]
  25. CD46 is phosphorylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. Lee, S.W., Bonnah, R.A., Higashi, D.L., Atkinson, J.P., Milgram, S.L., So, M. J. Cell Biol. (2002) [Pubmed]
  26. Activation of complement by mannose-binding lectin on isogenic mutants of Neisseria meningitidis serogroup B. Jack, D.L., Dodds, A.W., Anwar, N., Ison, C.A., Law, A., Frosch, M., Turner, M.W., Klein, N.J. J. Immunol. (1998) [Pubmed]
  27. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. Booth, J.W., Telio, D., Liao, E.H., McCaw, S.E., Matsuo, T., Grinstein, S., Gray-Owen, S.D. J. Biol. Chem. (2003) [Pubmed]
  28. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling. Massari, P., Visintin, A., Gunawardana, J., Halmen, K.A., King, C.A., Golenbock, D.T., Wetzler, L.M. J. Immunol. (2006) [Pubmed]
  29. Targeting of the pro-apoptotic VDAC-like porin (PorB) of Neisseria gonorrhoeae to mitochondria of infected cells. Müller, A., Günther, D., Brinkmann, V., Hurwitz, R., Meyer, T.F., Rudel, T. EMBO J. (2000) [Pubmed]
  30. Clinical manifestations of disseminated infection caused by Neisseria gonorrhoeae are linked to differences in bactericidal reactivity of infecting strains. Rice, P.A., Goldenberg, D.L. Ann. Intern. Med. (1981) [Pubmed]
  31. Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens. Kroll, J.S., Wilks, K.E., Farrant, J.L., Langford, P.R. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  32. Identification and characterization of the transferrin receptor from Neisseria meningitidis. Schryvers, A.B., Morris, L.J. Mol. Microbiol. (1988) [Pubmed]
  33. Molecular cloning and characterization of a proline iminopeptidase gene from Neisseria gonorrhoeae. Albertson, N.H., Koomey, M. Mol. Microbiol. (1993) [Pubmed]
WikiGenes - Universities