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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats.

Aldosterone increases the Na,K-ATPase function in renal cells involved in active Na(+) transport. Because the alveolar type 2 ( AT2) cells participate in active Na(+) transport, we studied whether aldosterone regulates the Na,K-ATPase in rat AT2 cells and whether aldosterone delivered by aerosols to spontaneously breathing rats affects edema clearance in a model of isolated-perfused lungs. The AT2 cells treated with aldosterone had increased Na,K-ATPase beta1-subunit mRNA and protein, which was associated with a 4-fold increase in the Na,K-ATPase hydrolytic activity and the ouabain-sensitive (86)Rb(+) uptake. In physiologic experiments, 24 h after aldosterone was delivered by aerosols to the rat air spaces, the active Na(+) transport and lung edema clearance increased by approximately 53% as compared with control rats and rats in which saline aerosols were delivered. The data suggest that increased active Na(+) transport and lung edema clearance induced by aldosterone is probably due to Na,K-ATPase regulation in alveolar epithelial cells. Conceivably, aldosterone may be used as a strategy to increase lung edema clearance.[1]

References

  1. Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats. Olivera, W.G., Ciccolella, D.E., Barquin, N., Ridge, K.M., Rutschman, D.H., Yeates, D.B., Sznajder, J.I. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
 
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