Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1).
We report the organization and chromosome localization of the mouse transcription elongation factor S-II gene (Tcea1). This gene was found to be a single copy gene consisting of 10 exons spanning approximately 30kb. Its organization was the same as those of the mouse testis-specific S-II gene (Tcea2) and Xenopus general S-II gene (xTFIIS.oA), but different from that of the human S-II gene family. We also identified a processed pseudogene (Tcea1-ps1) with a sequence highly homologous to those of S-II cDNAs but containing a translation termination codon within its open reading frame. Linkage analysis showed that Tcea1 and Tcea1-ps1 are mapped on mouse chromosomes 1 and 15, respectively. Relationships between Tcea1 and S-II cDNAs isolated so far are discussed.[1]References
- Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1). Ito, T., Seldin, M.F., Taketo, M.M., Kubo, T., Natori, S. Gene (2000) [Pubmed]
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