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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Active steroidogenesis in the normal rat skin.

Using the radiolabeled precursors of adrenal steroids (14)C-11-deoxycorticosterone (DOC) and (14)C-progesterone ((14)C-PROG) we demonstrate that rat skin can synthesize a number of steroids. TLC separation of labeled metabolites show that among the (14)C-steroid products, two co-migrate with corticosterone (B) and 11-dehydrocorticosterone (A) standards. Thus, normal rodent skin possesses steroidogenic activity that can be shown using progesterone or DOC as primary substrates.[1]


  1. Active steroidogenesis in the normal rat skin. Slominski, A., Gomez-Sanchez, C.E., Foecking, M.F., Wortsman, J. Biochim. Biophys. Acta (2000) [Pubmed]
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