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Chemical Compound Review

AC1NSU9Y     (10R,13S,17S)-17-(2- hydroxyethanoyl)-10,13...

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Disease relevance of 11-DEHYDROCORTICOSTERONE


High impact information on 11-DEHYDROCORTICOSTERONE


Biological context of 11-DEHYDROCORTICOSTERONE


Anatomical context of 11-DEHYDROCORTICOSTERONE


Associations of 11-DEHYDROCORTICOSTERONE with other chemical compounds




Analytical, diagnostic and therapeutic context of 11-DEHYDROCORTICOSTERONE


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  2. The 11 beta-OHSD inhibitor, carbenoxolone, enhances Na retention by aldosterone and 11-deoxycorticosterone. Morris, D.J., Souness, G.W. Am. J. Physiol. (1990) [Pubmed]
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  4. Lack of tissue glucocorticoid reactivation in 11beta -hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments. Yau, J.L., Noble, J., Kenyon, C.J., Hibberd, C., Kotelevtsev, Y., Mullins, J.J., Seckl, J.R. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. 11 beta-Hydroxysteroid dehydrogenase in cultured hippocampal cells reactivates inert 11-dehydrocorticosterone, potentiating neurotoxicity. Rajan, V., Edwards, C.R., Seckl, J.R. J. Neurosci. (1996) [Pubmed]
  6. Evidence that the 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD1) is regulated by pentose pathway flux. Studies in rat adipocytes and microsomes. McCormick, K.L., Wang, X., Mick, G.J. J. Biol. Chem. (2006) [Pubmed]
  7. Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. Gilmour, J.S., Coutinho, A.E., Cailhier, J.F., Man, T.Y., Clay, M., Thomas, G., Harris, H.J., Mullins, J.J., Seckl, J.R., Savill, J.S., Chapman, K.E. J. Immunol. (2006) [Pubmed]
  8. Type 1 11beta -hydroxysteroid dehydrogenase mediates glucocorticoid activation and insulin release in pancreatic islets. Davani, B., Khan, A., Hult, M., Mårtensson, E., Okret, S., Efendic, S., Jörnvall, H., Oppermann, U.C. J. Biol. Chem. (2000) [Pubmed]
  9. 11 beta-Hydroxysteroid dehydrogenase type 2 complementary deoxyribonucleic acid stably transfected into Chinese hamster ovary cells: specific inhibition by 11 alpha-hydroxyprogesterone. Morita, H., Zhou, M., Foecking, M.F., Gomez-Sanchez, E.P., Cozza, E.N., Gomez-Sanchez, C.E. Endocrinology (1996) [Pubmed]
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  11. 'Liver-type' 11 beta-hydroxysteroid dehydrogenase cDNA encodes reductase but not dehydrogenase activity in intact mammalian COS-7 cells. Low, S.C., Chapman, K.E., Edwards, C.R., Seckl, J.R. J. Mol. Endocrinol. (1994) [Pubmed]
  12. The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate. Kim, K.W., Wang, Z., Busby, J., Tsuruda, T., Chen, M., Hale, C., Castro, V.M., Svensson, S., Nybo, R., Xiong, F., Wang, M. Biochim. Biophys. Acta (2006) [Pubmed]
  13. Glucocorticoids and thyroid hormones stimulate biochemical and morphological differentiation of human fetal lung in organ culture. Gonzales, L.W., Ballard, P.L., Ertsey, R., Williams, M.C. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  14. 11beta-hydroxysteroid dehydrogenase is a predominant reductase in intact rat Leydig cells. Leckie, C.M., Welberg, L.A., Seckl, J.R. J. Endocrinol. (1998) [Pubmed]
  15. 11beta-hydroxysteroid dehydrogenase functions reversibly as an oxidoreductase in the rat hippocampus in vivo. Jellinck, P.H., Pavlides, C., Sakai, R.R., McEwen, B.S. J. Steroid Biochem. Mol. Biol. (1999) [Pubmed]
  16. Glucocorticoid metabolism in the cardiac interstitium: 11 beta-hydroxysteroid dehydrogenase activity in cardiac fibroblasts. Slight, S., Ganjam, V.K., Nonneman, D.J., Weber, K.T. J. Lab. Clin. Med. (1993) [Pubmed]
  17. Effect of high-fat diet on KKAy and ob/ob mouse liver and adipose tissue corticosterone and 11-dehydrocorticosterone concentrations. Alberts, P., Rönquist-Nii, Y., Larsson, C., Klingström, G., Engblom, L., Edling, N., Lidell, V., Berg, I., Edlund, P.O., Ashkzari, M., Sahaf, N., Norling, S., Berggren, V., Bergdahl, K., Forsgren, M., Abrahmsén, L. Horm. Metab. Res. (2005) [Pubmed]
  18. Developmental changes in glucocorticoid receptor and 11beta-hydroxysteroid dehydrogenase oxidative and reductive activities in rat Leydig cells. Ge, R.S., Hardy, D.O., Catterall, J.F., Hardy, M.P. Endocrinology (1997) [Pubmed]
  19. Developmental changes in rat renal 11 beta-hydroxysteroid dehydrogenase. Brem, A.S., Bina, B., Matheson, K.L., Barnes, J.L., Morris, D.J. Kidney Int. (1994) [Pubmed]
  20. An alternatively spliced rat mineralocorticoid receptor mRNA causing truncation of the steroid binding domain. Zhou, M.Y., Gomez-Sanchez, C.E., Gomez-Sanchez, E.P. Mol. Cell. Endocrinol. (2000) [Pubmed]
  21. 11 beta-hydroxysteroid dehydrogenases of the choriocarcinoma cell line JEG-3 and their inhibition by glycyrrhetinic acid and other natural substances. Gomez-Sanchez, E.P., Cox, D., Foecking, M., Ganjam, V., Gomez-Sanchez, C.E. Steroids (1996) [Pubmed]
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  24. Increased glucocorticoid receptor and 11{beta}-hydroxysteroid dehydrogenase type 1 expression in hepatocytes may contribute to the phenotype of type 2 diabetes in db/db mice. Liu, Y., Nakagawa, Y., Wang, Y., Sakurai, R., Tripathi, P.V., Lutfy, K., Friedman, T.C. Diabetes (2005) [Pubmed]
  25. Cloning, expression, and tissue distribution of the rat nicotinamide adenine dinucleotide-dependent 11 beta-hydroxysteroid dehydrogenase. Zhou, M.Y., Gomez-Sanchez, E.P., Cox, D.L., Cosby, D., Gomez-Sanchez, C.E. Endocrinology (1995) [Pubmed]
  26. 11 Beta-hydroxysteroid dehydrogenase type 2 in the postnatal and adult rat brain. Robson, A.C., Leckie, C.M., Seckl, J.R., Holmes, M.C. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  27. Distribution of 11 beta-hydroxysteroid dehydrogenase along the rabbit nephron. Bonvalet, J.P., Doignon, I., Blot-Chabaud, M., Pradelles, P., Farman, N. J. Clin. Invest. (1990) [Pubmed]
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