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Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor?

An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease ( HD) patients. Allele 263bp was significantly higher in PD patients (OR = 3.86) and ET patients (OR = 6.42) but not HD patients, compared with healthy controls. The association of allele 263bp with PD and ET suggests a possible etiologic link between these two conditions.[1]

References

  1. Polymorphism of NACP-Rep1 in Parkinson's disease: an etiologic link with essential tremor? Tan, E.K., Matsuura, T., Nagamitsu, S., Khajavi, M., Jankovic, J., Ashizawa, T. Neurology (2000) [Pubmed]
 
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