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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient.

A 30-year-old male patient with paranoid schizophrenia was on clozapine therapy for more than five years. Discontinuation of clozapine and an attempt to change his medication to sertindole has led to serious psychotic and somatic symptoms. After readministration of clozapine the psychotic symptoms rapidly disappeared. The patient was monitored by BPRS and PANSS positive and negative scale. Also clinical and labor parameters of the patient were monitored. The change of his medication from clozapine to sertindole was unsuccessful. This case report suggests that although atypical antipsychotics may be generally different from the classical neuroleptic drugs, there are also significant differences among the atypical antipsychotic drugs in their effects on the receptors of the central nervous system. Therefore the change of clozapine to another atypical antipsychotic medication in the clinical practice should be cross-tapered and the symptoms of withdrawal closely monitored.[1]


  1. Clozapine withdrawal symptoms after change to sertindole in a schizophrenic patient. Berecz, R., Glaub, T., Kellermann, M., de la Rubia, A., Llerena, A., Degrell, I. Pharmacopsychiatry (2000) [Pubmed]
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