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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety.

[formula: see text] The appended sugars in macrolide antibiotics are indispensable to the biological activities of these important drugs. In an effort to generate a set of novel macrolide derivatives, we have created a new analogue of methymycin and neomethymycin, antibiotics produced by Streptomyces venezuelae. This analogue 15 carrying a different sugar, D-quinovose, instead of D-desosamine, was constructed by taking advantage of targeted gene deletion combined with a specific pathway-independent C-3 reduction capability of the wild type S. venezuelae.[1]

References

  1. Biosynthesis of desosamine: construction of a new macrolide carrying a genetically designed sugar moiety. Borisova, S.A., Zhao, L., Sherman, D.H., Liu, H.W. Org. Lett. (1999) [Pubmed]
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