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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Platelet activation in depression and effects of sertraline treatment: An open-label study.

OBJECTIVE: The authors' goal was to determine whether sertraline attenuates the increased platelet activation seen among depressed patients. METHOD: They tested 21 otherwise healthy patients with untreated major depressive episode who were 25-52 years old and 21 age- and sex-matched comparison subjects. Patients received 6 weeks of sertraline treatment, and 17 returned for retesting. RESULTS: At baseline, the depressed patients had greater platelet secretion than the comparison subjects in response to collagen. Depressed patients with a family history of coronary disease had nonsignificantly greater wound-induced fibrinogen receptor binding than the other subjects. Platelet secretion in response to collagen was significantly reduced after treatment with sertraline. CONCLUSIONS: Sertraline diminished the increased platelet secretion found among depressed patients, although the findings are limited by a lack of a placebo control group.[1]

References

  1. Platelet activation in depression and effects of sertraline treatment: An open-label study. Markovitz, J.H., Shuster, J.L., Chitwood, W.S., May, R.S., Tolbert, L.C. The American journal of psychiatry. (2000) [Pubmed]
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