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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster.

The choice of sexual identity in Drosophila is determined by a system that measures the X chromosome to autosome ratio (X/A). This system depends upon unequal expression of X-linked numerator genes in 1X and 2X nuclei. The numerators activate a special Sxl promoter, Sxl-Pe, in 2X/2A nuclei, but not 1X/2A nuclei. By multimerizing a conserved Sxl-Pe sequence block, we generated a gain-of-function promoter, Sxl-PeGOF, that is inappropriately active in 1X/2A nuclei. GOF activity requires the X-linked unpaired (upd) gene, which encodes a ligand for the Drosophila JAK/STAT signaling pathway. upd also functions as a numerator element in regulating wild-type Sxl-Pe reporters. We demonstrate that the JAK kinase, Hopscotch, and the STAT DNA-binding protein, Marelle, are also required for Sxl-Pe activation.[1]

References

  1. The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Jinks, T.M., Polydorides, A.D., Calhoun, G., Schedl, P. Mol. Cell (2000) [Pubmed]
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