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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.

A disintegrin-like and metalloproteinase with thrombospondin type I motifs-1 ( ADAMTS-1) is an extracellular matrix-anchored metalloproteinase. In this study we have demonstrated that ADAMTS-1 is able to cleave a major cartilage proteoglycan, aggrecan. N-terminal sequencing analysis of the cleavage product revealed that ADAMTS-1 cleaves the Glu(1871)-Leu(1872) bond within the chondroitin sulfate attachment domain of aggrecan. In addition, deletional analysis demonstrated that the C-terminal spacer region of ADAMTS-1 is necessary to degrade aggrecan. These results suggest that ADAMTS-1 may be involved in the turnover of aggrecan in vivo.[1]

References

  1. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. Kuno, K., Okada, Y., Kawashima, H., Nakamura, H., Miyasaka, M., Ohno, H., Matsushima, K. FEBS Lett. (2000) [Pubmed]
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