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Gene Review

Ecm1  -  extracellular matrix protein 1

Mus musculus

Synonyms: AI663821, Extracellular matrix protein 1, Secretory component p85, p85
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Disease relevance of Ecm1


Psychiatry related information on Ecm1


High impact information on Ecm1


Chemical compound and disease context of Ecm1


Biological context of Ecm1


Anatomical context of Ecm1


Associations of Ecm1 with chemical compounds

  • BACKGROUND: Matrix metalloproteinases play a crucial role in the regulation of extracellular matrix turnover and structural artery wall remodeling [22].
  • In addition to ERK activation, an inflammatory stimulus, such as low m.w. hyaluronic acid from the extracellular matrix, must also be present [23].
  • Estrogen may be an important regulator of fibulin-3 expression, and this highlights a novel mechanism by which circulating estrogen may control the composition of the retinal extracellular matrix [24].
  • Because hCG regulated proteases and SERPINs (whereas testosterone did not), it could alter the proteolytic balance of Leydig cells and consequently the metabolism of extracellular matrix components [25].
  • JF-10-81 was found to block PC-3 cell attachment to various extracellular matrix components, mainly to vitronectin, the ligand of cell surface receptors integrin alphaVbeta3 and alphaVbeta5 [26].

Physical interactions of Ecm1


Enzymatic interactions of Ecm1


Regulatory relationships of Ecm1


Other interactions of Ecm1


Analytical, diagnostic and therapeutic context of Ecm1


  1. 3-Deazaadenosine mitigates arterial remodeling and hypertension in hyperhomocysteinemic mice. Ovechkin, A.V., Tyagi, N., Sen, U., Lominadze, D., Steed, M.M., Moshal, K.S., Tyagi, S.C. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  2. A novel sequence in the type IV collagen promoter binds nuclear proteins from Engelbreth-Holm-Swarm tumor. Bruggeman, L.A., Burbelo, P.D., Yamada, Y., Klotman, P.E. Oncogene (1992) [Pubmed]
  3. A Novel One-Armed Anti-c-Met Antibody Inhibits Glioblastoma Growth In vivo. Martens, T., Schmidt, N.O., Eckerich, C., Fillbrandt, R., Merchant, M., Schwall, R., Westphal, M., Lamszus, K. Clin. Cancer Res. (2006) [Pubmed]
  4. Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis. Verrecchia, F., Rossert, J., Mauviel, A. J. Invest. Dermatol. (2001) [Pubmed]
  5. Expression of chitinase-like proteins in the skin of chronic proliferative dermatitis (cpdm/cpdm) mice. Hogenesch, H., Dunham, A., Seymour, R., Renninger, M., Sundberg, J.P. Exp. Dermatol. (2006) [Pubmed]
  6. Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Chang, S., Young, B.D., Li, S., Qi, X., Richardson, J.A., Olson, E.N. Cell (2006) [Pubmed]
  7. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Liu, X., Zhao, Y., Gao, J., Pawlyk, B., Starcher, B., Spencer, J.A., Yanagisawa, H., Zuo, J., Li, T. Nat. Genet. (2004) [Pubmed]
  8. MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover. Holmbeck, K., Bianco, P., Caterina, J., Yamada, S., Kromer, M., Kuznetsov, S.A., Mankani, M., Robey, P.G., Poole, A.R., Pidoux, I., Ward, J.M., Birkedal-Hansen, H. Cell (1999) [Pubmed]
  9. Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2. Trommsdorff, M., Gotthardt, M., Hiesberger, T., Shelton, J., Stockinger, W., Nimpf, J., Hammer, R.E., Richardson, J.A., Herz, J. Cell (1999) [Pubmed]
  10. A role for dystroglycan in basement membrane assembly. Henry, M.D., Campbell, K.P. Cell (1998) [Pubmed]
  11. Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Terranova, V.P., Rohrbach, D.H., Martin, G.R. Cell (1980) [Pubmed]
  12. A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. Faassen, A.E., Schrager, J.A., Klein, D.J., Oegema, T.R., Couchman, J.R., McCarthy, J.B. J. Cell Biol. (1992) [Pubmed]
  13. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Luo, J., Sobkiw, C.L., Logsdon, N.M., Watt, J.M., Signoretti, S., O'Connell, F., Shin, E., Shim, Y., Pao, L., Neel, B.G., Depinho, R.A., Loda, M., Cantley, L.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  14. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Yumoto, K., Ishijima, M., Rittling, S.R., Tsuji, K., Tsuchiya, Y., Kon, S., Nifuji, A., Uede, T., Denhardt, D.T., Noda, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  15. A disaccharide that inhibits tumor necrosis factor alpha is formed from the extracellular matrix by the enzyme heparanase. Lider, O., Cahalon, L., Gilat, D., Hershkoviz, R., Siegel, D., Margalit, R., Shoseyov, O., Cohen, I.R. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Recombinant human extracellular matrix protein 1 inhibits alkaline phosphatase activity and mineralization of mouse embryonic metatarsals in vitro. Deckers, M.M., Smits, P., Karperien, M., Ni, J., Tylzanowski, P., Feng, P., Parmelee, D., Zhang, J., Bouffard, E., Gentz, R., Löwik, C.W., Merregaert, J. Bone (2001) [Pubmed]
  17. Molecular cloning and characterization of the mouse Ecm1 gene and its 5' regulatory sequences. Smits, P., Bhalerao, J., Merregaert, J. Gene (1999) [Pubmed]
  18. Heart extracellular matrix gene expression profile in the vitamin D receptor knockout mice. Rahman, A., Hershey, S., Ahmed, S., Nibbelink, K., Simpson, R.U. J. Steroid Biochem. Mol. Biol. (2007) [Pubmed]
  19. Alternative splicing of the Endo16 transcript produces differentially expressed mRNAs during sea urchin gastrulation. Godin, R.E., Urry, L.A., Ernst, S.G. Dev. Biol. (1996) [Pubmed]
  20. Insulin-like growth factor binding protein 5 induces skin fibrosis: A novel murine model for dermal fibrosis. Yasuoka, H., Jukic, D.M., Zhou, Z., Choi, A.M., Feghali-Bostwick, C.A. Arthritis Rheum. (2006) [Pubmed]
  21. Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis. Malik, M., Bakshi, C.S., McCabe, K., Catlett, S.V., Shah, A., Singh, R., Jackson, P.L., Gaggar, A., Metzger, D.W., Melendez, J.A., Blalock, J.E., Sellati, T.J. J. Immunol. (2007) [Pubmed]
  22. Mice lacking the gene encoding for MMP-9 and resistance artery reactivity. Su, J., Palen, D.I., Lucchesi, P.A., Matrougui, K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. Activation of the MAPK, ERK, following Leishmania amazonensis Infection of Macrophages. Yang, Z., Mosser, D.M., Zhang, X. J. Immunol. (2007) [Pubmed]
  24. Transcriptional regulation and expression of the dominant drusen gene FBLN3 (EFEMP1) in mammalian retina. Blackburn, J., Tarttelin, E.E., Gregory-Evans, C.Y., Moosajee, M., Gregory-Evans, K. Invest. Ophthalmol. Vis. Sci. (2003) [Pubmed]
  25. The mouse testis is the source of various serine proteases and serine proteinase inhibitors (SERPINs): Serine proteases and SERPINs identified in Leydig cells are under gonadotropin regulation. Odet, F., Verot, A., Le Magueresse-Battistoni, B. Endocrinology (2006) [Pubmed]
  26. A conjugate of camptothecin and a somatostatin analog against prostate cancer cell invasion via a possible signaling pathway involving PI3K/Akt, alphaVbeta3/alphaVbeta5 and MMP-2/-9. Sun, L.C., Luo, J., Mackey, L.V., Fuselier, J.A., Coy, D.H. Cancer Lett. (2007) [Pubmed]
  27. Mouse fibulin-2 gene. Complete exon-intron organization and promoter characterization. Grässel, S., Sicot, F.X., Gotta, S., Chu, M.L. Eur. J. Biochem. (1999) [Pubmed]
  28. Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. Guvakova, M.A., Yakubov, L.A., Vlodavsky, I., Tonkinson, J.L., Stein, C.A. J. Biol. Chem. (1995) [Pubmed]
  29. Collagenase is expressed by rabbit VX2 tumour cells in syngeneic and xenogeneic hosts. Gavrilovic, J., Hembry, R.M., Reynolds, J.J., Murphy, G. Matrix (1989) [Pubmed]
  30. The epidermal growth factor receptor is required to maintain the proliferative population in the basal compartment of epidermal tumors. Hansen, L.A., Woodson, R.L., Holbus, S., Strain, K., Lo, Y.C., Yuspa, S.H. Cancer Res. (2000) [Pubmed]
  31. Inhibition of c-Abl tyrosine kinase activity by filamentous actin. Woodring, P.J., Hunter, T., Wang, J.Y. J. Biol. Chem. (2001) [Pubmed]
  32. Metal-catalyzed oxidation of extracellular matrix increases macrophage nitric oxide generation. Mattana, J., Margiloff, L., Chaplia, L., Chow, A., Singhal, P.C. Kidney Int. (1998) [Pubmed]
  33. Expression of dentin matrix protein 1 (DMP1) during fracture healing. Toyosawa, S., Kanatani, N., Shintani, S., Kobata, M., Yuki, M., Kishino, M., Ijuhin, N., Komori, T. Bone (2004) [Pubmed]
  34. Antitumor effects of the molecule-downsized immunoconjugate composed of lidamycin and Fab' fragment of monoclonal antibody directed against type IV collagenase. Fengqiang, W., Boyang, S., Yongsu, Z. Sci. China, C, Life Sci. (2004) [Pubmed]
  35. PAI-1 promotes extracellular matrix deposition in the airways of a murine asthma model. Oh, C.K., Ariue, B., Alban, R.F., Shaw, B., Cho, S.H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  36. Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa. Akiyama, H., Chaboissier, M.C., Behringer, R.R., Rowitch, D.H., Schedl, A., Epstein, J.A., de Crombrugghe, B. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  37. Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B.R., Miura, N., Carlsson, P. Development (2006) [Pubmed]
  38. Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Farina, H.G., Pomies, M., Alonso, D.F., Gomez, D.E. Oncol. Rep. (2006) [Pubmed]
  39. Transcriptional activation of the alpha1(I) procollagen gene and up-regulation of alpha1(I) and alpha1(III) procollagen messenger RNA in dermal fibroblasts from tight skin 2 mice. Christner, P.J., Hitraya, E.G., Peters, J., McGrath, R., Jiménez, S.A. Arthritis Rheum. (1998) [Pubmed]
  40. The retinoblastoma protein modulates expression of genes coding for diverse classes of proteins including components of the extracellular matrix. Rohde, M., Warthoe, P., Gjetting, T., Lukas, J., Bartek, J., Strauss, M. Oncogene (1996) [Pubmed]
  41. Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells. Segade, F., Mecham, R.P. Biochim. Biophys. Acta (2005) [Pubmed]
  42. Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription. Zhang, W., Ou, J., Inagaki, Y., Greenwel, P., Ramirez, F. J. Biol. Chem. (2000) [Pubmed]
  43. Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis. Chiang, C.K., Sheu, M.L., Hung, K.Y., Wu, K.D., Liu, S.H. Kidney Int. (2006) [Pubmed]
  44. Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Xu, T., Bianco, P., Fisher, L.W., Longenecker, G., Smith, E., Goldstein, S., Bonadio, J., Boskey, A., Heegaard, A.M., Sommer, B., Satomura, K., Dominguez, P., Zhao, C., Kulkarni, A.B., Robey, P.G., Young, M.F. Nat. Genet. (1998) [Pubmed]
  45. Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Choquet, D., Felsenfeld, D.P., Sheetz, M.P. Cell (1997) [Pubmed]
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